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James B Mitchell

Explore the profile of James B Mitchell including associated specialties, affiliations and a list of published articles. Areas
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Articles 235
Citations 7926
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Recent Articles
1.
Kishimoto S, Horie K, Devasahayam N, Yamashita K, Gadisetti C, Yamamoto K, et al.
bioRxiv . 2025 Feb; PMID: 39896573
Renal oxygenation is essential for maintaining kidney function. Disruptions in oxygen delivery can lead to renal hypoxia, which can exacerbate kidney injury through multiple pathways, including inflammation, oxidative stress, and...
2.
Morgan E, Saleh A, Cornelius S, Carlson S, Toni T, Cheng H, et al.
Cancer Res Commun . 2024 Oct; 4(11):2903-2918. PMID: 39392349
Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets...
3.
Sowers A, Gohain S, Edmondson E, Choudhuri R, Krishna M, Cook J, et al.
Radiat Res . 2024 Aug; 202(4):639-648. PMID: 39142650
The rationale of this study stems from the concern of a radiation-induced accident or terrorist-mediated nuclear attack resulting in large populations of people exposed to nonlethal radiation doses or after...
4.
Huang J, Davenport A, Heffernan K, Debela T, Marshall C, McKenzie J, et al.
J Am Chem Soc . 2024 Jul; 146(30):21099-21109. PMID: 39011684
Anion sensing technology is motivated by the widespread and critical roles played by anions in biological systems and the environment. Electrochemical approaches comprise a major portion of this field but...
5.
Bylicky M, Shankavaram U, Aryankalayil M, Chopra S, Naz S, Sowers A, et al.
Mol Cancer Ther . 2024 Feb; 23(4):577-588. PMID: 38359816
Treatments involving radiation and chemotherapy alone or in combination have improved patient survival and quality of life. However, cancers frequently evade these therapies due to adaptation and tumor evolution. Given...
6.
Morgan E, Toni T, Viswanathan R, Robbins Y, Yang X, Cheng H, et al.
Cell Death Differ . 2023 Apr; 30(5):1382-1396. PMID: 37055579
TNFα is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but several cancers, including head and neck squamous cell carcinomas (HNSCC), display resistance to TNFα due to activation of...
7.
Otowa Y, Kishimoto S, Saida Y, Yamashita K, Yamamoto K, Chandramouli G, et al.
Antioxid Redox Signal . 2023 Apr; 39(7-9):432-444. PMID: 37051681
Pancreatic ductal adenocarcinomas (PDACs) form hypovascular and hypoxic tumors, which are difficult to treat with current chemotherapy regimens. Gemcitabine (GEM) is often used as a first-line treatment for PDACs but...
8.
Huang J, Marshall C, Ojha K, Shen M, Golledge S, Kadota K, et al.
J Am Chem Soc . 2023 Mar; 145(11):6257-6269. PMID: 36893341
Redox intercalation involves coupled ion-electron motion within host materials, finding extensive application in energy storage, electrocatalysis, sensing, and optoelectronics. Monodisperse MOF nanocrystals, compared to their bulk phases, exhibit accelerated mass...
9.
Toni T, Viswanathan R, Robbins Y, Gunti S, Yang X, Huynh A, et al.
Cancers (Basel) . 2023 Feb; 15(4). PMID: 36831373
Head and neck squamous cell carcinoma (HNSCC) remains a prevalent diagnosis with current treatment options that include radiotherapy and immune-mediated therapies, in which tumor necrosis factor-α (TNFα) is a key...
10.
Cook J, Sowers A, Choudhuri R, Gadisetti C, Edmondson E, Gohain S, et al.
J Radiat Res . 2022 Oct; 64(1):24-32. PMID: 36253079
Non-lethal doses of ionizing radiation (IR) delivered to humans because of terrorist events, nuclear accidents or radiotherapy can result in carcinogenesis. Means of protecting against carcinogenesis are lacking. We questioned...