N Neamati
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Explore the profile of N Neamati including associated specialties, affiliations and a list of published articles.
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44
Citations
561
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Recent Articles
11.
Neamati N, Marchand C, Pommier Y
Adv Pharmacol
. 2000 Oct;
49:147-65.
PMID: 11013763
No abstract available.
12.
Pommier Y, Marchand C, Neamati N
Antiviral Res
. 2000 Sep;
47(3):139-48.
PMID: 10974366
HIV-1 integrase is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. A number of inhibitors have been reported in the past 8...
13.
Pluymers W, Neamati N, Pannecouque C, Fikkert V, Marchand C, Burke Jr T, et al.
Mol Pharmacol
. 2000 Aug;
58(3):641-8.
PMID: 10953059
The antiviral activity of L-chicoric acid against HIV-1 has been attributed previously to the inhibition of HIV-1 integration. This conclusion was based on the inhibition of integrase activity in enzymatic...
14.
Taktakishvili M, Neamati N, Pommier Y, Nair V
Bioorg Med Chem Lett
. 2000 Mar;
10(3):249-51.
PMID: 10698446
The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the...
15.
Wang Y, Neamati N, Jacob J, Palmer I, Stahl S, Kaufman J, et al.
Cell
. 1999 Nov;
99(4):433-42.
PMID: 10571185
We present the solution structure of MAP30, a plant protein with anti-HIV and anti-tumor activities. Structural analysis and subsequent biochemical assays lead to several novel discoveries. First, MAP30 acts like...
16.
Neamati N, Turpin J, Winslow H, Christensen J, Williamson K, Orr A, et al.
J Med Chem
. 1999 Aug;
42(17):3334-41.
PMID: 10464020
A series of thiazolothiazepines were prepared and tested against purified human immunodeficiency virus type-1 integrase (HIV-1 IN) and viral replication. Structure-activity studies reveal that the compounds possessing the pentatomic moiety...
17.
Pommier Y, Neamati N
Adv Virus Res
. 1999 Jun;
52:427-58.
PMID: 10384246
Integration of the viral DNA into a host cell chromosome is an essential step for HIV replication and maintenance of persistent infection. Two viral factors are essential for integration: the...
18.
Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin J, Aberham C, et al.
J Med Chem
. 1999 Apr;
42(8):1401-14.
PMID: 10212126
The present study was undertaken to examine structural features of L-chicoric acid (3) which are important for potency against purified HIV-1 integrase and for reported cytoprotective effects in cell-based systems....
19.
Zhang J, Neamati N, Pommier Y, Nair V
Bioorg Med Chem Lett
. 1999 Jan;
8(14):1887-90.
PMID: 9873453
5'-Monophosphates of several novel dideoxynucleosides bearing tricyclic nucleobases were synthesized. Both linear and angular ring-extended analogs of isomeric dideoxyadenosine 5'-monophosphate were discovered to have moderate to good inhibition of the...
20.
Hong H, Neamati N, Winslow H, Christensen J, Orr A, Pommier Y, et al.
Antivir Chem Chemother
. 1998 Dec;
9(6):461-72.
PMID: 9865384
The rapid emergence of human immunodeficiency virus (HIV) strains resistant to available drugs implies that effective treatment modalities will require the use of a combination of drugs targeting different sites...