Y Pommier
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Explore the profile of Y Pommier including associated specialties, affiliations and a list of published articles.
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251
Citations
5723
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Recent Articles
1.
Baechler S, Saha L, Factor V, Chitnis C, Dhall A, Becker D, et al.
bioRxiv
. 2024 Oct;
PMID: 39372760
High fat (HF) diet is a major factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatis (MASH), and mitochondria have been proposed to play a role...
2.
Baechler S, Factor V, Dalla Rosa I, Ravji A, Becker D, Khiati S, et al.
Nat Commun
. 2019 Jan;
10(1):83.
PMID: 30622257
Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in...
3.
Solier S, Zhang Y, Ballestrero A, Pommier Y, Zoppoli G
Curr Cancer Drug Targets
. 2012 Mar;
12(4):356-71.
PMID: 22385513
Although several drugs have been designed in the last few years to target specific key pathways and functions in colorectal cancer (CRC), the backbone of CRC treatment is still made...
4.
Martin S, Wu Z, Gehlhaus K, Jones T, Zhang Y, Guha R, et al.
Curr Cancer Drug Targets
. 2011 Aug;
11(8):976-86.
PMID: 21834757
In an effort to develop strategies that improve the efficacy of existing anticancer agents, we have conducted a siRNA-based RNAi screen to identify genes that, when targeted by siRNA, improve...
5.
Zoppoli G, Solier S, Reinhold W, Liu H, Connelly Jr J, Monks A, et al.
Oncogene
. 2011 Jul;
31(4):403-18.
PMID: 21765476
CHEK2 encodes a serine/threonine kinase (Chk2) activated by ATM in response to DNA double-strand breaks. On the one hand, CHEK2 has been described as a tumor suppressor with proapoptotic, cell-cycle...
6.
Pourquier P, Kohlhagen G, Ueng L, Pommier Y
Methods Mol Med
. 2011 Mar;
28:95-110.
PMID: 21374031
DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes that play an essential role in transcription, replication, chromosome segregation, and DNA repair. The basic enzymatic reaction of...
7.
Mazumder A, Neamati N, Sunder S, Owen J, Pommier Y
Methods Mol Med
. 2011 Feb;
24:327-38.
PMID: 21331920
Two critical events are the signature of the life cycle of retroviruses (1). The first is reverse transcription, whereby the single-stranded RNA genome of the retrovirus is copied into double-stranded...
8.
Lebedeva N, Rechkunova N, Agama K, Pommier Y, Lavrik O
Biochemistry (Mosc)
. 2009 Nov;
74(11):1278-84.
PMID: 19916945
The interaction of human recombinant DNA topoisomerase 1 (Top1) with linear and circular DNA structures containing a nick or short gap but lacking a specific Top1 recognition site was studied....
9.
Meng L, Kohn K, Pommier Y
Oncogene
. 2007 Feb;
26(33):4806-16.
PMID: 17297446
Aminoflavone (AF, NSC 686,288) is beginning clinical trials. It induces replication-mediated histone H2AX phosphorylation, DNA-protein crosslinks and activates p53. Here, we studied p21(CIP1/WAF1) and Mdm2 responses to AF. Although p53...
10.
Furuta T, Hayward R, Meng L, Takemura H, Aune G, Bonner W, et al.
Oncogene
. 2006 Jan;
25(20):2839-49.
PMID: 16407843
This study provides evidence for the importance of p21(CDKN1A) for the repair of replication-mediated DNA double-strand breaks (DSBs) induced by topoisomerase I. We report that defects of p21(CDKN1A) and p53...