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Murali Prakriya

Explore the profile of Murali Prakriya including associated specialties, affiliations and a list of published articles. Areas
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Articles 78
Citations 6568
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Recent Articles
1.
Novakovic M, Prakriya M
Curr Opin Neurobiol . 2024 Dec; 90:102940. PMID: 39673911
Astrocytes are the most prevalent glial cells of the brain and mediate vital roles in the development and function of the nervous system. Astrocytes, along with microglia, also play key...
2.
Susperreguy S, Yamashita M, Choi C, Liao Y, Burch L, Blankenship T, et al.
Proc Natl Acad Sci U S A . 2024 Nov; 121(49):e2411389121. PMID: 39602257
Using genetically engineered mice and cell lines derived from genetically engineered mice we show that depletion of ER delimited Ca stores activates heteromeric Ca entry (SOCE) channels formed obligatorily, but...
3.
Korshunov K, Prakriya M
Annu Rev Physiol . 2024 Nov; 87(1):173-199. PMID: 39586031
Store-operated Ca2+ entry (SOCE) is a widespread mechanism of cellular Ca2+ signaling that arises from Ca2+ influx across the plasma membrane through the Orai family of calcium channels in response...
4.
Datta S, Gupta A, Jagetiya K, Tiwari V, Yamashita M, Ammann S, et al.
bioRxiv . 2024 Nov; PMID: 39484379
CRAC channels enable calcium entry from the extracellular space in response to a variety of stimuli and are crucial for gene expression and granule exocytosis in lymphocytes. Here we find...
5.
Jairaman A, Prakriya M
Arterioscler Thromb Vasc Biol . 2024 Feb; 44(4):772-783. PMID: 38385293
Airway epithelial cells play an indispensable role in protecting the lung from inhaled pathogens and allergens by releasing an array of mediators that orchestrate inflammatory and immune responses when confronted...
6.
Elbaz B, Darwish A, Vardy M, Isaac S, Tokars H, Dzhashiashvili Y, et al.
Neuron . 2023 Nov; 112(2):247-263.e6. PMID: 37924811
Oligodendrocytes are the primary producers of many extracellular matrix (ECM)-related proteins found in the CNS. Therefore, oligodendrocytes play a critical role in the determination of brain stiffness, node of Ranvier...
7.
Novakovic M, Korshunov K, Grant R, Martin M, Valencia H, Budinger G, et al.
Nat Commun . 2023 Sep; 14(1):5500. PMID: 37679321
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood. In this study, we...
8.
Shum A, Zaichick S, McElroy G, DAlessandro K, Alasady M, Novakovic M, et al.
Proc Natl Acad Sci U S A . 2023 Apr; 120(17):e2217396120. PMID: 37068235
Octopamine is a well-established invertebrate neurotransmitter involved in fight or flight responses. In mammals, its function was replaced by epinephrine. Nevertheless, it is present at trace amounts and can modulate...
9.
Courjaret R, Prakriya M, Machaca K
J Physiol . 2023 Apr; 602(8):1449-1462. PMID: 37029630
Store operated Ca entry (SOCE) is a ubiquitous signalling module with established roles in the immune system, secretion and muscle development. Recent evidence supports a complex role for SOCE in...
10.
Yeung P, Yamashita M, Prakriya M
Elife . 2023 Feb; 12. PMID: 36806330
Ca release-activated Ca (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca sensor. A hallmark of CRAC channels is fast...