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» Authors » Moustafa S Abusaif

Moustafa S Abusaif

Explore the profile of Moustafa S Abusaif including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 51
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Yousry A Ammar
Ahmed Ragab
Hamdy Khamees Thabet
Mohamed A Salem
Ahmed Alshehri
Abida Ash Mohd
Mohd Imran
Mohamed Hamdy Helal
Saleh Ibrahim Alaqel
Nirvana A Gohar
Published In
RSC Adv
Bioorg Chem
Sci Rep
Drug Dev Res
Eur J Med Chem
Affiliations
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Recent Articles
1.
A novel chitosan-Schiff bases bearing a new quinoxaline moiety as an approach for potent antimicrobial agent: Synthesis, characterization and in vitro assessments
Barakat A, Ehagali G, Kamoun E, Abusaif M, Owda M, Ghazy M, et al.
Carbohydr Polym . 2025 Jan; 352():123205. PMID: 39843106
This study aims to enhance the antimicrobial properties of chitosan through preparing novel chitosan Schiff bases via coupling with 4-formylphenyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonate (B5) where, different molar ratios of B5 were used...
2.
Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm : design, characterization, bio-evaluation, toxicological effectiveness, and study their mode of action
Elsisi D, Abusaif M, El-Said E, Elqady E, Salem M, Ammar Y, et al.
RSC Adv . 2025 Jan; 15(2):1391-1406. PMID: 39822566
Herein, novel thiazolo[4,5-]quinoxalin-2-ones 2-6 and thiazolo[4,5-]quinoxalin-2(3)-imines 7-9 were synthesized and characterized using elemental analysis, IR spectroscopy, and H/C NMR to confirm their structures. The efficacy of the newly designed thiazolo-quinoxalines...
3.
Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation
Abusaif M, Ragab A, Fayed E, Ammar Y, Gowifel A, Hassanin S, et al.
Bioorg Chem . 2024 Dec; 154:108023. PMID: 39644617
Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary treatment option for advanced...
4.
Pharmacological investigation of new niclosamide-based isatin hybrids as antiproliferative, antioxidant, and apoptosis inducers
Omran M, Kamal M, Ammar Y, Abusaif M, Ismail M, Mansour H
Sci Rep . 2024 Aug; 14(1):19818. PMID: 39191850
A group of Niclosamide-linked isatin hybrids (Xo, X1, and X2) was created and examined using IR, HNMR, C NMR, and mass spectrometry. These hybrids' cytotoxicity, antioxidant, cell cycle analysis, and...
5.
Insight into divergent chemical modifications of chitosan biopolymer: Review
Elnaggar E, Abusaif M, Abdel-Baky Y, Ragab A, Omer A, Ibrahim I, et al.
Int J Biol Macromol . 2024 Aug; 277(Pt 2):134347. PMID: 39094872
Chitosan is used in many applications due to its biodegradability, biocompatibility, nontoxicity, nonadhesiveness, and film-forming capabilities. Chitosan has antibacterial and antifungal activities, which are two of its other desirable attributes....
6.
Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with in-silico ADMET and docking simulation
Khamees Thabet H, Ammar Y, Imran M, Hamdy Helal M, Ibrahim Alaqel S, Alshehri A, et al.
Bioorg Chem . 2024 Jul; 151:107671. PMID: 39067419
Diabetes mellitus type 2 (T2DM) can be managed by targeting dipeptidyl peptidase-4 (DPP-4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this context, a...
7.
Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting -amylase, and -glucosidase: synthesis, molecular docking, and ADMET studies
Gohar N, Fayed E, Ammar Y, Abu Ali O, Ragab A, Mahfoz A, et al.
J Enzyme Inhib Med Chem . 2024 Jun; 39(1):2367128. PMID: 38913598
Inhibition of α-glucosidase and -amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes. Indeno[1,2-] quinoxalines-carrying thiazole hybrids were created...
8.
New prospective insecticidal agents based on thiazolo[4,5-b]quinoxaline derivatives against cotton leafworm Spodoptera litura (Fabricius): Design, synthesis, toxicological, morphology, histological, and biomedical studies
Ragab A, Elsisi D, Elqady E, El-Said E, Salem M, Ammar Y, et al.
Pestic Biochem Physiol . 2024 Jun; 202:105943. PMID: 38879303
In this study, a new series of thiazolo[4,5-b]quinoxaline derivatives 3-8 were synthesized by treating 2,3-dichloroquinoxaline with thiosemicarbazone and thiourea derivatives under reflux conditions. The chemical structure of the newly designed...
9.
Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation
Khamees Thabet H, Ragab A, Imran M, Hamdy Helal M, Ibrahim Alaqel S, Alshehri A, et al.
Eur J Med Chem . 2024 Jun; 275:116589. PMID: 38878516
Uncontrolled diabetes can lead to hyperglycemia, which causes neuropathy, heart attacks, retinopathy, and nervous system damage over time, therefore, controlling hyperglycemia using potential drug target inhibitors is a promising strategy....
10.
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α-glucosidase, α-amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation
Ragab A, Salem M, Ammar Y, Aboulthana W, Helal M, Abusaif M
Drug Dev Res . 2024 Jun; 85(4):e22216. PMID: 38831547
A new series of quinoxaline-sulfonamide derivatives 3-12 were synthesized using fragment-based drug design by reaction of quinoxaline sulfonyl chloride (QSC) with different amines and hydrazines. The quinoxaline-sulfonamide derivatives were evaluated...