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» Authors » Nirvana A Gohar

Nirvana A Gohar

Explore the profile of Nirvana A Gohar including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 27
Followers 0
Related Specialties
Biochemistry
Chemistry
Pharmacy
Top 10 Co-Authors
Eman A Fayed
Yousry A Ammar
Ahmed Ragab
Moustafa S Abusaif
Ahmed B M Mehany
Amel M Farrag
Triveena M Ramsis
Maha A Ebrahim
Ashraf H Bayoumi
Ghada E Ahmed
Published In
Bioorg Chem
Mol Divers
J Enzyme Inhib Med Chem
Arch Pharm (Weinheim)
Affiliations
Soon will be listed here.
Recent Articles
1.
Novel Pyrrolidine-bearing quinoxaline inhibitors of DNA Gyrase, RNA polymerase and spike glycoprotein
Ebrahim M, Ramsis T, Gohar N, Metwally S, Rushdi A, Fayed E
Bioorg Chem . 2025 Jan; 156:108218. PMID: 39879826
Anti-infective agents are a class of drugs used to prevent, treat, or control infections caused by microorganisms such as bacteria, viruses, fungi, and parasites. They play a crucial role in...
2.
Exploring a novel thiazole derivatives hybrid with fluorinated-indenoquinoxaline as dual inhibitors targeting VEGFR2/AKT and apoptosis inducers against hepatocellular carcinoma with docking simulation
Abusaif M, Ragab A, Fayed E, Ammar Y, Gowifel A, Hassanin S, et al.
Bioorg Chem . 2024 Dec; 154:108023. PMID: 39644617
Hepatocellular carcinoma (HCC) ranks as the third most prevalent reason for cancer-related death on a global scale. Tyrosine kinase inhibitors (TKIs) continue to be the primary treatment option for advanced...
3.
Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targeting -amylase, and -glucosidase: synthesis, molecular docking, and ADMET studies
Gohar N, Fayed E, Ammar Y, Abu Ali O, Ragab A, Mahfoz A, et al.
J Enzyme Inhib Med Chem . 2024 Jun; 39(1):2367128. PMID: 38913598
Inhibition of α-glucosidase and -amylase are key tactics for managing blood glucose levels. Currently, stronger, and more accessible inhibitors are needed to treat diabetes. Indeno[1,2-] quinoxalines-carrying thiazole hybrids were created...
4.
Development of new spiro[1,3]dithiine-4,11'-indeno[1,2-b]quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular modeling simulation
Ragab A, Abusaif M, Gohar N, Aboul-Magd D, Fayed E, Ammar Y
Bioorg Chem . 2022 Dec; 131:106307. PMID: 36481380
Multi-drug resistant microbes have become a severe threat to human health and arise a worldwide concern. A total of fifteen spiro-1,3-dithiinoindenoquinoxaline derivatives 2-7 were synthesized and evaluated for their biological...
5.
Upregulation of BAX and caspase-3, as well as downregulation of Bcl-2 during treatment with indeno[1,2-b]quinoxalin derivatives, mediated apoptosis in human cancer cells
Fayed E, Gohar N, Farrag A, Ammar Y
Arch Pharm (Weinheim) . 2022 Feb; 355(5):e2100454. PMID: 35174895
Cancer is the world's foremost cause of death. There are over 100 different forms of cancer. Cancers are frequently named after the organs or tissues in which they develop. As...
6.
In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies
Fayed E, Ammar Y, Ragab A, Gohar N, Mehany A, Farrag A
Bioorg Chem . 2020 May; 100:103951. PMID: 32450392
In this study, anti-proliferative effects of twenty-seven indeno[1,2-b]quinoxalin-11-one derivatives were investigated in three human cancer cell lines, namely: the colon cancer cell line HCT-116, the liver cancer cell line HepG-2,...
7.
Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents
Fayed E, Eissa S, Bayoumi A, Gohar N, Mehany A, Ammar Y
Mol Divers . 2018 Aug; 23(1):165-181. PMID: 30099687
3,5-Diamino-4-(3-trifluoromethylphenyldiazenyl)-1H-pyrazole was used as a starting scaffold for the synthesis of new pyrazole-based heterocycles to study their effects on the proliferation of three human cancer cell lines; human liver carcinoma...