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Morwenna Y Porter

Explore the profile of Morwenna Y Porter including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 80
Followers 0
Related Specialties
General Medicine
Biochemistry
Molecular Biology
Top 10 Co-Authors
Michael R Koelle
Eric W Hewitt
Sheena E Radford
Andrew L Hellewell
Katy E Routledge
Sara E Mole
Wei-Feng Xue
Ombretta Foresti
Toral Jakhria
Nicola Gover
Published In
J Biol Chem
PLoS One
J Neurosci Res
Mol Biol Cell
Prog Mol Biol Transl Sci
Affiliations
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Recent Articles
1.
β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
Jakhria T, Hellewell A, Porter M, Jackson M, Tipping K, Xue W, et al.
J Biol Chem . 2014 Nov; 289(52):35781-94. PMID: 25378395
Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium...
2.
Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells
Hellewell A, Foresti O, Gover N, Porter M, Hewitt E
PLoS One . 2014 Jun; 9(6):e98900. PMID: 24910990
Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic lymphohistiocytosis type 4 (FHL-4), a disorder caused by mutations in the gene encoding the SNARE protein...
3.
Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils
Porter M, Routledge K, Radford S, Hewitt E
PLoS One . 2011 Nov; 6(11):e27353. PMID: 22096558
The formation of insoluble amyloid fibrils is associated with an array of devastating human diseases. Dialysis-related amyloidosis (DRA) is a severe complication of hemodialysis that results in the progressive destruction...
4.
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins
Porter M, Xie K, Pozharski E, Koelle M, Martemyanov K
J Biol Chem . 2010 Oct; 285(52):41100-12. PMID: 20959458
Regulators of G protein signaling (RGS) proteins of the R7 subfamily limit signaling by neurotransmitters in the brain and by light in the retina. They form obligate complexes with the...
5.
Insights into RGS protein function from studies in Caenorhabditis elegans
Porter M, Koelle M
Prog Mol Biol Transl Sci . 2010 Apr; 86:15-47. PMID: 20374712
The nematode worm, Caenorhabditis elegans, contains orthologs of most regulator of G protein signaling (RGS) protein subfamilies and all four G protein α-subunit subfamilies found in mammals. Every C. elegans...
6.
RSBP-1 is a membrane-targeting subunit required by the Galpha(q)-specific but not the Galpha(o)-specific R7 regulator of G protein signaling in Caenorhabditis elegans
Porter M, Koelle M
Mol Biol Cell . 2009 Nov; 21(2):232-43. PMID: 19923320
Regulator of G protein signaling (RGS) proteins inhibit G protein signaling by activating Galpha GTPase activity, but the mechanisms that regulate RGS activity are not well understood. The mammalian R7...
7.
Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1
Porter M, Turmaine M, Mole S
J Neurosci Res . 2005 Jan; 79(6):836-48. PMID: 15672447
Infantile neuronal ceroid lipofuscinosis (INCL; Batten disease) is a severe neurodegenerative disorder of childhood characterized by the accumulation of autofluorescent storage material in lysosomes. It is caused by mutation of...