Andrew L Hellewell
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Explore the profile of Andrew L Hellewell including associated specialties, affiliations and a list of published articles.
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12
Citations
418
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Recent Articles
1.
Hellewell A, Heesom K, Jepson M, Adams J
Am J Physiol Cell Physiol
. 2022 Feb;
322(4):C624-C644.
PMID: 35196163
The matricellular glycoprotein thrombospondin-1 (TSP1) has complex roles in the extracellular matrix (ECM) and at cell surfaces, but relatively little is known about its intracellular associations prior to secretion. To...
2.
Lommel M, Strompen J, Hellewell A, Balasubramanian G, Christofidou E, Thomson A, et al.
Sci Rep
. 2018 Aug;
8(1):11753.
PMID: 30082916
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan...
3.
Hellewell A, Rosini S, Adams J
J Vis Exp
. 2017 Jan;
(119).
PMID: 28117783
The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes. However, the isolation of ECM, from tissues or...
4.
Hellewell A, Adams J
Bioessays
. 2016 Jan;
38(1):77-88.
PMID: 26735930
In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneous microenvironment that has important supportive and instructive roles. Although the primary site of action of ECM proteins is extracellular, evidence...
5.
Hellewell A, Gong X, Scharich K, Christofidou E, Adams J
Biosci Rep
. 2015 Jul;
35(3).
PMID: 26182380
Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions. Unlike the structural components of the ECM that...
6.
Jakhria T, Hellewell A, Porter M, Jackson M, Tipping K, Xue W, et al.
J Biol Chem
. 2014 Nov;
289(52):35781-94.
PMID: 25378395
Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium...
7.
Hellewell A, Foresti O, Gover N, Porter M, Hewitt E
PLoS One
. 2014 Jun;
9(6):e98900.
PMID: 24910990
Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic lymphohistiocytosis type 4 (FHL-4), a disorder caused by mutations in the gene encoding the SNARE protein...
8.
Sheynis T, Friediger A, Xue W, Hellewell A, Tipping K, Hewitt E, et al.
Biophys J
. 2013 Aug;
105(3):745-55.
PMID: 23931322
Amyloid fibril accumulation is a pathological hallmark of several devastating disorders, including Alzheimer's disease, prion diseases, type II diabetes, and others. Although the molecular factors responsible for amyloid pathologies have...
9.
Milanesi L, Sheynis T, Xue W, Orlova E, Hellewell A, Jelinek R, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(50):20455-60.
PMID: 23184970
Protein misfolding and aggregation cause serious degenerative conditions such as Alzheimer's, Parkinson, and prion diseases. Damage to membranes is thought to be one of the mechanisms underlying cellular toxicity of...
10.
Woods L, Platt G, Hellewell A, Hewitt E, Homans S, Ashcroft A, et al.
Nat Chem Biol
. 2011 Aug;
7(10):730-9.
PMID: 21873994
Although small molecules that modulate amyloid formation in vitro have been identified, significant challenges remain in determining precisely how these species act. Here we describe the identification of rifamycin SV...