Moritz Schaefer
Overview
Explore the profile of Moritz Schaefer including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
53
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0
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Recent Articles
1.
Schaefer M, Reichl S, Ter Horst R, Nicolas A, Krausgruber T, Piras F, et al.
Comput Biol Med
. 2024 Jun;
178:108796.
PMID: 38909448
Background: Computational simulation of biological processes can be a valuable tool for accelerating biomedical research, but usually requires extensive domain knowledge and manual adaptation. Large language models (LLMs) such as...
2.
Simmler P, Cortijo C, Koch L, Galliker P, Angori S, Bolck H, et al.
Cell Rep
. 2022 Aug;
40(8):111266.
PMID: 36001976
Mutations in the splicing factor SF3B1 are frequently occurring in various cancers and drive tumor progression through the activation of cryptic splice sites in multiple genes. Recent studies also demonstrate...
3.
Schaefer M, Nabih A, Spies D, Hermes V, Bodak M, Wischnewski H, et al.
EMBO Rep
. 2022 Jul;
23(9):e54762.
PMID: 35899551
MicroRNA (miRNA) loaded Argonaute (AGO) complexes regulate gene expression via direct base pairing with their mRNA targets. Previous works suggest that up to 60% of mammalian transcripts might be subject...
4.
Muller M, Schaefer M, Fah T, Spies D, Hermes V, Ngondo R, et al.
Stem Cell Reports
. 2022 Apr;
17(5):1070-1080.
PMID: 35452597
The Argonaute proteins (AGOs) are well known for their role in post-transcriptional gene silencing in the microRNA (miRNA) pathway. Here we show that in mouse embryonic stem cells, AGO1&2 serve...
5.
Rissel R, Schaefer M, Kamuf J, Ruemmler R, Riedel J, Mohnke K, et al.
PeerJ
. 2022 Mar;
10:e13024.
PMID: 35265399
Background: Interorgan cross-talk describes the phenomenon in which a primarily injured organ causes secondary damage to a distant organ. This cross-talk is well known between the lung and brain. One...
6.
Muller M, Fah T, Schaefer M, Hermes V, Luitz J, Stalder P, et al.
Life Sci Alliance
. 2022 Mar;
5(6).
PMID: 35236760
Argonaute proteins (AGOs), which play an essential role in cytosolic post-transcriptional gene silencing, have been also reported to function in nuclear processes like transcriptional activation or repression, alternative splicing and,...
7.
Grodzki M, Bluhm A, Schaefer M, Tagmount A, Russo M, Sobh A, et al.
Genome Med
. 2022 Jan;
14(1):10.
PMID: 35086559
Background: The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered globally, there is still a great...
8.
Schaefer M, Clevert D, Weiss B, Steffen A
Bioinformatics
. 2018 Nov;
35(13):2309-2310.
PMID: 30445568
Summary: Single-guide RNAs (sgRNAs) targeting the same gene can significantly vary in terms of efficacy and specificity. PAVOOC (Prediction And Visualization of On- and Off-targets for CRISPR) is a web-based...