Peter Stepper
Overview
Explore the profile of Peter Stepper including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
333
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0
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Recent Articles
1.
Schaefer M, Reichl S, Ter Horst R, Nicolas A, Krausgruber T, Piras F, et al.
Comput Biol Med
. 2024 Jun;
178:108796.
PMID: 38909448
Background: Computational simulation of biological processes can be a valuable tool for accelerating biomedical research, but usually requires extensive domain knowledge and manual adaptation. Large language models (LLMs) such as...
2.
dordevic M, Stepper P, Feuerstein-Akgoz C, Gerhauser C, Paunovic V, Tolic A, et al.
Front Endocrinol (Lausanne)
. 2023 Apr;
14:1134478.
PMID: 37008919
Introduction: Beta cell dysfunction by loss of beta cell identity, dedifferentiation, and the presence of polyhormonal cells are main characteristics of diabetes. The straightforward strategy for curing diabetes implies reestablishment...
3.
Liu C, Toth R, Bakr A, Goyal A, Islam M, Breuer K, et al.
Cancers (Basel)
. 2021 Jun;
13(10).
PMID: 34070078
Radiotherapy, a common component in cancer treatment, can induce adverse effects including fibrosis in co-irradiated tissues. We previously showed that differential DNA methylation at an enhancer of diacylglycerol kinase alpha...
4.
Simple Synthesis of Functionalized Paramagnetic Beads for Nucleic Acid Purification and Manipulation
Oberacker P, Stepper P, Bond D, Hipp K, Hore T, Jurkowski T
Bio Protoc
. 2021 Mar;
9(20):e3394.
PMID: 33654895
The purification of nucleic acids is one of the most common procedures employed in modern molecular biology laboratories. Typically, commercial column-based protocols are utilized to isolate DNA or RNA from...
5.
Oberacker P, Stepper P, Bond D, Hohn S, Focken J, Meyer V, et al.
PLoS Biol
. 2019 Jan;
17(1):e3000107.
PMID: 30629605
Current molecular biology laboratories rely heavily on the purification and manipulation of nucleic acids. Yet, commonly used centrifuge- and column-based protocols require specialised equipment, often use toxic reagents, and are...
6.
Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
Saunderson E, Stepper P, Gomm J, Hoa L, Morgan A, Allen M, et al.
Nat Commun
. 2017 Nov;
8(1):1450.
PMID: 29133799
Aberrant promoter DNA hypermethylation is a hallmark of cancer; however, whether this is sufficient to drive cellular transformation is not clear. To investigate this question, we use a CRISPR-dCas9 epigenetic...
7.
Stepper P, Kungulovski G, Jurkowska R, Chandra T, Krueger F, Reinhardt R, et al.
Nucleic Acids Res
. 2016 Dec;
45(4):1703-1713.
PMID: 27899645
DNA methylation plays a critical role in the regulation and maintenance of cell-type specific transcriptional programs. Targeted epigenome editing is an emerging technology to specifically regulate cellular gene expression in...
8.
Jurkowski T, Ravichandran M, Stepper P
Clin Epigenetics
. 2015 Mar;
7:18.
PMID: 25741388
Epigenetics is currently one of the hottest topics in basic and biomedical research. However, to date, most of the studies have been descriptive in nature, designed to investigate static distribution...