Moritz Gartlgruber
Overview
Explore the profile of Moritz Gartlgruber including associated specialties, affiliations and a list of published articles.
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13
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1146
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Recent Articles
1.
Alborzinia H, Florez A, Kreth S, Bruckner L, Yildiz U, Gartlgruber M, et al.
Nat Cancer
. 2022 Apr;
3(4):471-485.
PMID: 35484422
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance....
2.
Gartlgruber M, Sharma A, Quintero A, Dreidax D, Jansky S, Park Y, et al.
Nat Cancer
. 2022 Feb;
2(1):114-128.
PMID: 35121888
Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the...
3.
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
Jansky S, Sharma A, Korber V, Quintero A, Toprak U, Wecht E, et al.
Nat Genet
. 2021 Mar;
53(5):683-693.
PMID: 33767450
Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the single-cell transcriptomes of neuroblastomas...
4.
Afanasyeva E, Gartlgruber M, Ryl T, Decaesteker B, Denecker G, Monke G, et al.
Life Sci Alliance
. 2021 Mar;
4(5).
PMID: 33658318
The migrational propensity of neuroblastoma is affected by cell identity, but the mechanisms behind the divergence remain unknown. Using RNAi and time-lapse imaging, we show that ADRN-type NB cells exhibit...
5.
Hartlieb S, Sieverling L, Nadler-Holly M, Ziehm M, Toprak U, Herrmann C, et al.
Nat Commun
. 2021 Feb;
12(1):1269.
PMID: 33627664
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas...
6.
Musa J, Cidre-Aranaz F, Aynaud M, Orth M, Knott M, Mirabeau O, et al.
Nat Commun
. 2019 Sep;
10(1):4128.
PMID: 31511524
Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here, we demonstrate in EwS how...
7.
Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, et al.
Science
. 2018 Dec;
362(6419):1165-1170.
PMID: 30523111
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor...
8.
Decaesteker B, Denecker G, Van Neste C, Dolman E, Van Loocke W, Gartlgruber M, et al.
Nat Commun
. 2018 Nov;
9(1):4866.
PMID: 30451831
Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and...
9.
Henrich K, Bender S, Saadati M, Dreidax D, Gartlgruber M, Shao C, et al.
Cancer Res
. 2016 Sep;
76(18):5523-37.
PMID: 27635046
The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid progression despite intensive multimodal therapy. This diversity is not fully explained by known genetic aberrations, suggesting the possibility...
10.
The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells
Textor S, Bossler F, Henrich K, Gartlgruber M, Pollmann J, Fiegler N, et al.
Oncoimmunology
. 2016 Sep;
5(7):e1116674.
PMID: 27622013
Natural Killer (NK) cells are innate effector cells that are able to recognize and eliminate tumor cells through engagement of their surface receptors. NKp30 is a potent activating NK cell...