Moo Je Sung
Overview
Explore the profile of Moo Je Sung including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
88
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0
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Recent Articles
1.
Axford J, Sung M, Manchester J, Chin D, Jain M, Shin Y, et al.
J Med Chem
. 2021 Apr;
64(8):4744-4761.
PMID: 33822618
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of...
2.
Cheung A, Hurley B, Kerrigan R, Shu L, Chin D, Shen Y, et al.
J Med Chem
. 2018 Nov;
61(24):11021-11036.
PMID: 30407821
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function...
3.
Serrano-Wu M, Coppola G, Gong Y, Neubert A, Chatelain R, Clairmont K, et al.
ACS Med Chem Lett
. 2014 Jun;
3(5):411-5.
PMID: 24900485
High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an...
4.
Cho Y, Borland M, Brain C, Chen C, Cheng H, Chopra R, et al.
J Med Chem
. 2010 Nov;
53(22):7938-57.
PMID: 21038853
Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of...
5.
Sung M, Pang J, Park S, Cha J
Org Lett
. 2003 Jun;
5(12):2137-40.
PMID: 12790548
[reaction: see text] In connection with the known diyne-ene [2 + 2 + 2] cycloaddition reactions mediated by titanium aryloxides, the ability of titanium alkoxides to promote coupling of a...
6.
Sung M, Lee H, Lee H, Cha J
J Org Chem
. 2003 Mar;
68(6):2205-8.
PMID: 12636382
Starting with the tricyclic core 2b, annulation to form the 13-membered western ring of sarain A has been achieved to afford the macrocycle 30a by initial construction of the sterically...