Rajeev Sivasankaran
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Explore the profile of Rajeev Sivasankaran including associated specialties, affiliations and a list of published articles.
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22
Citations
1730
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Recent Articles
1.
Casaletto K, Saloner R, Kornak J, Staffaroni A, Villeda S, Paolillo E, et al.
Brain Commun
. 2025 Jan;
7(1):fcae432.
PMID: 39816189
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance...
2.
Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, et al.
Neurology
. 2024 Jul;
103(3):e209585.
PMID: 38959435
Background And Objectives: Identification of fluid biomarkers for progressive supranuclear palsy (PSP) is critical to enhance therapeutic development. We implemented unbiased DNA aptamer (SOMAmer) proteomics to identify novel CSF PSP...
3.
Saloner R, Staffaroni A, Dammer E, Johnson E, Paolillo E, Wise A, et al.
Res Sq
. 2024 Apr;
PMID: 38585969
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. We leveraged aptamer-based proteomics (> 4,000 proteins) to identify dysregulated communities of...
4.
Gubser Keller C, Shin Y, Monteys A, Renaud N, Beibel M, Teider N, et al.
Nat Commun
. 2022 Mar;
13(1):1150.
PMID: 35241644
Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. The mutant HTT (mHTT) protein causes neuronal dysfunction,...
5.
Monteys A, Hundley A, Ranum P, Tecedor L, Muehlmatt A, Lim E, et al.
Nature
. 2022 Feb;
602(7897):E25.
PMID: 35105975
No abstract available.
6.
Theil D, Valdez R, Darribat K, Doelemeyer A, Sivasankaran R, Hartmann A
Biol Open
. 2021 Sep;
10(10).
PMID: 34528068
Branaplam is a therapeutic agent currently in clinical development for the treatment of infants with type 1 spinal muscular atrophy (SMA). Since preclinical studies showed that branaplam had cell-cycle arrest...
7.
Thijssen E, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, et al.
Lancet Neurol
. 2021 Aug;
20(9):739-752.
PMID: 34418401
Background: Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau pathology. We compared the diagnostic value of both...
8.
Monteys A, Hundley A, Ranum P, Tecedor L, Muehlmatt A, Lim E, et al.
Nature
. 2021 Jul;
596(7871):291-295.
PMID: 34321659
So far, gene therapies have relied on complex constructs that cannot be finely controlled. Here we report a universal switch element that enables precise control of gene replacement or gene...
9.
Rojas J, Wang P, Staffaroni A, Heller C, Cobigo Y, Wolf A, et al.
Neurology
. 2021 Apr;
96(18):e2296-e2312.
PMID: 33827960
Objective: We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression. Methods: Baseline plasma NfL...
10.
Axford J, Sung M, Manchester J, Chin D, Jain M, Shin Y, et al.
J Med Chem
. 2021 Apr;
64(8):4744-4761.
PMID: 33822618
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of...