Monica E Neugebauer
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Explore the profile of Monica E Neugebauer including associated specialties, affiliations and a list of published articles.
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9
Citations
221
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Recent Articles
1.
Zhang E, Neugebauer M, Krasnow N, Liu D
Nat Commun
. 2024 Feb;
15(1):1697.
PMID: 38402281
TadA-derived cytosine base editors (TadCBEs) enable programmable C•G-to-T•A editing while retaining the small size, high on-target activity, and low off-target activity of TadA deaminases. Existing TadCBEs, however, exhibit residual A•T-to-G•C...
2.
Doman J, Pandey S, Neugebauer M, An M, Davis J, Randolph P, et al.
Cell
. 2023 Sep;
186(18):3983-4002.e26.
PMID: 37657419
Prime editing enables a wide variety of precise genome edits in living cells. Here we use protein evolution and engineering to generate prime editors with reduced size and improved efficiency....
3.
Slater J, Lin C, Neugebauer M, McBride M, Sil D, Nair M, et al.
Biochemistry
. 2023 Aug;
62(16):2480-2491.
PMID: 37542461
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three nongaseous substrates must bind to activate...
4.
Slater J, Neugebauer M, McBride M, Sil D, Lin C, Katch B, et al.
bioRxiv
. 2023 May;
PMID: 37205437
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br ), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three non-gaseous substrates must bind to...
5.
Kissman E, Neugebauer M, Sumida K, Swenson C, Sambold N, Marchand J, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2214512120.
PMID: 36913566
Biocatalytic C-H activation has the potential to merge enzymatic and synthetic strategies for bond formation. Fe/αKG-dependent halogenases are particularly distinguished for their ability both to control selective C-H activation as...
6.
Neugebauer M, Hsu A, Arbab M, Krasnow N, McElroy A, Pandey S, et al.
Nat Biotechnol
. 2022 Nov;
41(5):673-685.
PMID: 36357719
Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base editors (ABEs). To develop a CBE that retains...
7.
McBride M, Nair M, Sil D, Slater J, Neugebauer M, Chang M, et al.
Biochemistry
. 2022 Apr;
61(8):689-702.
PMID: 35380785
The enzyme BesC from the -thynyl-l-erine biosynthetic pathway in fragments 4-chloro-l-lysine (produced from l-Lysine by BesD) to ammonia, formaldehyde, and 4-chloro-l-allylglycine and can analogously fragment l-Lys itself. BesC belongs to...
8.
Neugebauer M, Kissman E, Marchand J, Pelton J, Sambold N, Millar D, et al.
Nat Chem Biol
. 2021 Dec;
18(2):171-179.
PMID: 34937913
Fe/α-ketoglutarate (Fe/αKG)-dependent enzymes offer a promising biocatalytic platform for halogenation chemistry owing to their ability to functionalize unactivated C-H bonds. However, relatively few radical halogenases have been identified to date,...
9.
Neugebauer M, Sumida K, Pelton J, McMurry J, Marchand J, Chang M
Nat Chem Biol
. 2019 Sep;
15(10):1009-1016.
PMID: 31548692
The integration of synthetic and biological catalysis enables new approaches to the synthesis of small molecules by combining the high selectivity of enzymes with the reaction diversity offered by synthetic...