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Amie K Boal

Explore the profile of Amie K Boal including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 65
Citations 1677
Followers 0
Related Specialties
Biochemistry
Chemistry
Science
Top 10 Co-Authors
J Martin Bollinger Jr
Carsten Krebs
Amy C Rosenzweig
Alexey Silakov
Squire J Booker
Andrew J Mitchell
Molly J McBride
Jacqueline K Barton
Wei-Chen Chang
Noah P Dunham
Published In
J Am Chem Soc
Biochemistry
Proc Natl Acad Sci U S A
Science
Nature
Affiliations
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Recent Articles
1.
Modulating metal-centered dimerization of a lanthanide chaperone protein for separation of light lanthanides
Larrinaga W, Jung J, Lin C, Boal A, Cotruvo Jr J
Proc Natl Acad Sci U S A . 2024 Oct; 121(45):e2410926121. PMID: 39467132
Elucidating details of biology's selective uptake and trafficking of rare earth elements, particularly the lanthanides, has the potential to inspire sustainable biomolecular separations of these essential metals for myriad modern...
2.
Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Wenger E, Martinie R, Ushimaru R, Pollock C, Sil D, Li A, et al.
J Am Chem Soc . 2024 Aug; 146(35):24271-24287. PMID: 39172701
Hyoscyamine 6β-hydroxylase (H6H) is an iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase that produces the prolifically administered antinausea drug, scopolamine. After its namesake hydroxylation reaction, H6H then couples the newly installed C6...
3.
Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)
Lin C, Munoz A, Laremore T, Silakov A, Krebs C, Boal A, et al.
ACS Catal . 2023 Sep; 12(12):6968-6979. PMID: 37744570
Important bioactive natural products, including prostaglandin H and artemisinin, contain reactive endoperoxides. Known enzymatic pathways for endoperoxide installation require multiple hydrogen-atom transfers (HATs). For example, iron(II)- and 2-oxoglutarate-dependent verruculogen synthase...
4.
Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Slater J, Lin C, Neugebauer M, McBride M, Sil D, Nair M, et al.
Biochemistry . 2023 Aug; 62(16):2480-2491. PMID: 37542461
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three nongaseous substrates must bind to activate...
5.
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
Mattocks J, Jung J, Lin C, Dong Z, Yennawar N, Featherston E, et al.
Nature . 2023 May; 618(7963):87-93. PMID: 37259003
Technologically critical rare-earth elements are notoriously difficult to separate, owing to their subtle differences in ionic radius and coordination number. The natural lanthanide-binding protein lanmodulin (LanM) is a sustainable alternative...
6.
Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Slater J, Neugebauer M, McBride M, Sil D, Lin C, Katch B, et al.
bioRxiv . 2023 May; PMID: 37205437
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br ), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three non-gaseous substrates must bind to...
7.
Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily
McBride M, Pope S, Nair M, Sil D, Salas-Sola X, Krebs C, et al.
Methods Mol Biol . 2023 Apr; 2648:123-154. PMID: 37039989
Nonheme diiron enzymes harness the chemical potential of oxygen to catalyze challenging reactions in biology. In their resting state, these enzymes have a diferrous cofactor that is coordinated by histidine...
8.
Discovery, structure and mechanism of a tetraether lipid synthase
Lloyd C, Iwig D, Wang B, Cossu M, Metcalf W, Boal A, et al.
Nature . 2022 Jul; 609(7925):197-203. PMID: 35882349
Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, high salinity, and low or high pH values. In some archaea, such...
9.
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes
Jeyachandran V, Boal A
Curr Opin Chem Biol . 2022 May; 68:102153. PMID: 35512465
Radical S-adenosylmethionine (SAM) enzymes use a common catalytic core for diverse transformations. While all radical SAM enzymes bind a FeS cluster via a characteristic tri-cysteine motif, many bind additional metal...
10.
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
McBride M, Nair M, Sil D, Slater J, Neugebauer M, Chang M, et al.
Biochemistry . 2022 Apr; 61(8):689-702. PMID: 35380785
The enzyme BesC from the -thynyl-l-erine biosynthetic pathway in fragments 4-chloro-l-lysine (produced from l-Lysine by BesD) to ammonia, formaldehyde, and 4-chloro-l-allylglycine and can analogously fragment l-Lys itself. BesC belongs to...