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J Martin Bollinger Jr

Explore the profile of J Martin Bollinger Jr including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 132
Citations 4258
Followers 0
Related Specialties
Chemistry
Biochemistry
Science
Top 10 Co-Authors
Carsten Krebs
Amie K Boal
Eric W Barr
Lana Saleh
Wei-Chen Chang
Alexey Silakov
Megan L Matthews
Wei Jiang
Ryan J Martinie
Laura M K Dassama
Published In
J Am Chem Soc
Biochemistry
Proc Natl Acad Sci U S A
Science
Curr Opin Chem Biol
Affiliations
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Recent Articles
1.
Structural Elucidation of the Reduced Mn(III)/Fe(III) Intermediate of the Radical-Initiating Metallocofactor in Ribonucleotide Reductase
Martinie R, Livada J, Kothiya N, Bollinger Jr J, Krebs C, Silakov A
Biochemistry . 2025 Feb; 64(5):1157-1167. PMID: 39960811
Ribonucleotide reductases (RNRs) are the sole source of deoxyribonucleotides for DNA synthesis and repair across all organisms and carry out their reaction via a radical mechanism. RNR from generates its...
2.
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Shishikura K, Li J, Chen Y, McKnight N, Bustin K, Barr E, et al.
bioRxiv . 2025 Jan; PMID: 39803451
The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicines as a therapy for preeclampsia. Despite its...
3.
Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Wenger E, Martinie R, Ushimaru R, Pollock C, Sil D, Li A, et al.
J Am Chem Soc . 2024 Aug; 146(35):24271-24287. PMID: 39172701
Hyoscyamine 6β-hydroxylase (H6H) is an iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase that produces the prolifically administered antinausea drug, scopolamine. After its namesake hydroxylation reaction, H6H then couples the newly installed C6...
4.
Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code
Hardy F, Quesne M, Gerard E, Zhao J, Ortmayer M, Taylor C, et al.
ACS Catal . 2024 Aug; 14(15):11584-11590. PMID: 39114090
The ability to introduce noncanonical amino acids as axial ligands in heme enzymes has provided a powerful experimental tool for studying the structure and reactivity of their Fe=O ("ferryl") intermediates....
5.
An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO
Pan J, Wenger E, Lin C, Zhang B, Sil D, Schaperdoth I, et al.
Biochemistry . 2024 Jun; 63(13):1674-1683. PMID: 38898603
-Acetylnorloline synthase (LolO) is one of several iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases that catalyze sequential reactions of different types in the biosynthesis of valuable natural products. LolO hydroxylates C2 of...
6.
Steric Perturbation of the Grob-like Final Step of Ethylene-Forming Enzyme Enables 3-Hydroxypropionate and Propylene Production
Burke E, Copeland R, Dixit Y, Krebs C, Bollinger Jr J
J Am Chem Soc . 2024 Jan; 146(3):1977-1983. PMID: 38226594
Ethylene-forming enzyme (EFE) is an iron(II)-dependent dioxygenase that fragments 2-oxoglutarate (2OG) to ethylene (from C3 and C4) and 3 equivs of carbon dioxide (from C1, C2, and C5). This major...
7.
Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)
Lin C, Munoz A, Laremore T, Silakov A, Krebs C, Boal A, et al.
ACS Catal . 2023 Sep; 12(12):6968-6979. PMID: 37744570
Important bioactive natural products, including prostaglandin H and artemisinin, contain reactive endoperoxides. Known enzymatic pathways for endoperoxide installation require multiple hydrogen-atom transfers (HATs). For example, iron(II)- and 2-oxoglutarate-dependent verruculogen synthase...
8.
An iron-sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities
Maio N, Raza M, Li Y, Zhang D, Bollinger Jr J, Krebs C, et al.
Proc Natl Acad Sci U S A . 2023 Aug; 120(33):e2303860120. PMID: 37552760
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors to replicate its genome and transcribe its genes....
9.
Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Slater J, Lin C, Neugebauer M, McBride M, Sil D, Nair M, et al.
Biochemistry . 2023 Aug; 62(16):2480-2491. PMID: 37542461
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three nongaseous substrates must bind to activate...
10.
Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Slater J, Neugebauer M, McBride M, Sil D, Lin C, Katch B, et al.
bioRxiv . 2023 May; PMID: 37205437
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl or Br ), the halogenation target ("prime substrate"), and dioxygen. In well-studied cases, the three non-gaseous substrates must bind to...