Mona C Loffler
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Explore the profile of Mona C Loffler including associated specialties, affiliations and a list of published articles.
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7
Citations
84
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Recent Articles
1.
Karwen T, Kolczynska-Matysiak K, Gross C, Loffler M, Friedrich M, Loza-Valdes A, et al.
EMBO Mol Med
. 2023 Jul;
15(9):e16858.
PMID: 37490001
Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the...
2.
Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera J, et al.
Biochem Biophys Res Commun
. 2022 May;
612:119-125.
PMID: 35523049
Kinases represent one of the largest druggable families of proteins. Importantly, many kinases are aberrantly activated/de-activated in multiple organs during obesity, which contributes to the development of diabetes and associated...
3.
Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, et al.
EMBO Mol Med
. 2021 May;
13(5):e13548.
PMID: 33949105
Lipids are the most energy-dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine...
4.
Loffler M, Betz M, Blondin D, Augustin R, Sharma A, Tseng Y, et al.
Mol Metab
. 2021 Apr;
51:101237.
PMID: 33878401
Background: A chronic imbalance of energy intake and energy expenditure results in excess fat storage. The obesity often caused by this overweight is detrimental to the health of millions of...
5.
El-Merahbi R, Viera J, Valdes A, Kolczynska K, Reuter S, Loffler M, et al.
Genes Dev
. 2020 Mar;
34(7-8):495-510.
PMID: 32139423
Obesity-induced diabetes affects >400 million people worldwide. Uncontrolled lipolysis (free fatty acid release from adipocytes) can contribute to diabetes and obesity. To identify future therapeutic avenues targeting this pathway, we...
6.
Mayer A, Loffler M, Loza Valdes A, Schmitz W, El-Merahbi R, Viera J, et al.
Sci Signal
. 2019 Aug;
12(593).
PMID: 31387939
Hepatic activation of protein kinase C (PKC) isoforms by diacylglycerol (DAG) promotes insulin resistance and contributes to the development of type 2 diabetes (T2D). The closely related protein kinase D...
7.
Loffler M, Mayer A, Viera J, Valdes A, El-Merahbi R, Ade C, et al.
EMBO J
. 2018 Nov;
37(22).
PMID: 30389661
Nutrient overload in combination with decreased energy dissipation promotes obesity and diabetes. Obesity results in a hormonal imbalance, which among others activates G protein-coupled receptors utilizing diacylglycerol (DAG) as secondary...