Moira A McMahon
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Explore the profile of Moira A McMahon including associated specialties, affiliations and a list of published articles.
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25
Citations
1250
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Recent Articles
1.
McMahon M, Rahdar M, Mukhopadhyay S, Bui H, Hart C, Damle S, et al.
Mol Ther Nucleic Acids
. 2023 Apr;
32:289-301.
PMID: 37096163
Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent...
2.
McMahon M, Rahdar M
Methods Mol Biol
. 2020 Sep;
2162:49-60.
PMID: 32926377
CRISPR-based gene editing in mammalian cells is a powerful research tool which has demonstrated efficient site-specific gene modifications and is showing promise as a therapeutic for patients with genetic diseases....
3.
Nechemia-Arbely Y, Miga K, Shoshani O, Aslanian A, McMahon M, Lee A, et al.
Nat Cell Biol
. 2019 Jun;
21(6):743-754.
PMID: 31160708
Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites...
4.
Melamed Z, Lopez-Erauskin J, Baughn M, Zhang O, Drenner K, Sun Y, et al.
Nat Neurosci
. 2019 Jan;
22(2):180-190.
PMID: 30643298
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that TDP-43 regulates expression of the neuronal...
5.
Kim D, Han J, Ly P, Ye Q, McMahon M, Myung K, et al.
Nat Commun
. 2018 Oct;
9(1):4354.
PMID: 30341343
The mitotic checkpoint ensures accurate chromosome segregation through assembly of the mitotic checkpoint complex (MCC), a soluble inhibitor of the anaphase-promoting complex/cyclosome (APC/C) produced by unattached kinetochores. MCC is also...
6.
McMahon M, Prakash T, Cleveland D, Bennett C, Rahdar M
Mol Ther
. 2018 Apr;
26(5):1228-1240.
PMID: 29650467
CRISPR-based gene editing is a powerful technology for engineering mammalian genomes. It holds the potential as a therapeutic, although much-needed in vivo delivery systems have yet to be established. Here,...
7.
8.
Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon M, et al.
Cell Rep
. 2016 Nov;
17(9):2394-2404.
PMID: 27880912
Human centromeres are defined by chromatin containing the histone H3 variant CENP-A assembled onto repetitive alphoid DNA sequences. By inducing rapid, complete degradation of endogenous CENP-A, we now demonstrate that...
9.
Malmersjo S, Di Palma S, Diao J, Lai Y, Pfuetzner R, Wang A, et al.
EMBO J
. 2016 Jul;
35(16):1810-21.
PMID: 27402227
Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an α-helical bundle to pull two membranes together. Here, we show that vesicle fusion can be...
10.
Rahdar M, McMahon M, Prakash T, Swayze E, Bennett C, Cleveland D
Proc Natl Acad Sci U S A
. 2015 Nov;
112(51):E7110-7.
PMID: 26589814
Genome editing with the clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 nuclease system is a powerful technology for manipulating genomes, including introduction of gene disruptions or corrections. Here we develop...