Mohsin M Naqvi
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Explore the profile of Mohsin M Naqvi including associated specialties, affiliations and a list of published articles.
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11
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232
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Recent Articles
1.
Banerjee A, Mathew S, Naqvi M, Yilmaz S, Zacharopoulou M, Doruker P, et al.
Sci Adv
. 2024 May;
10(22):eadn2208.
PMID: 38820156
PR65 is the HEAT repeat scaffold subunit of the heterotrimeric protein phosphatase 2A (PP2A) and an archetypal tandem repeat protein. Its conformational mechanics plays a crucial role in PP2A function...
2.
Naqvi M, Lee L, Montaguth O, Diffin F, Szczelkun M
Nat Chem Biol
. 2022 Jul;
18(9):1014-1022.
PMID: 35836018
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a is widely used for genome editing and diagnostics, so it is important to understand how RNA-guided DNA recognition activates the cleavage of the...
3.
Naqvi M, Avellaneda M, Roth A, Koers E, Roland A, Sunderlikova V, et al.
Sci Adv
. 2022 Mar;
8(9):eabl6293.
PMID: 35245117
The collapse of polypeptides is thought important to protein folding, aggregation, intrinsic disorder, and phase separation. However, whether polypeptide collapse is modulated in cells to control protein states is unclear....
4.
Mullally G, van Aelst K, Naqvi M, Diffin F, Karvelis T, Gasiunas G, et al.
Nucleic Acids Res
. 2020 Jun;
48(12):6811-6823.
PMID: 32496535
A key aim in exploiting CRISPR-Cas is gRNA engineering to introduce additional functionalities, ranging from individual nucleotide changes that increase efficiency of on-target binding to the inclusion of larger functional...
5.
Moayed F, Bezrukavnikov S, Naqvi M, Groitl B, Cremers C, Kramer G, et al.
Biophys J
. 2019 Nov;
118(1):85-95.
PMID: 31757359
Holdase chaperones are known to be central to suppressing aggregation, but how they affect substrate conformations remains poorly understood. Here, we use optical tweezers to study how the holdase Hsp33...
6.
Avellaneda M, Koers E, Naqvi M, Tans S
Protein Sci
. 2017 Mar;
26(7):1291-1302.
PMID: 28342267
Protein folding is well known to be supervised by a dedicated class of proteins called chaperones. However, the core mode of action of these molecular machines has remained elusive due...
7.
Marcoux J, Mangione P, Porcari R, Degiacomi M, Verona G, Taylor G, et al.
EMBO Mol Med
. 2015 Aug;
7(10):1337-49.
PMID: 26286619
The mechanisms underlying transthyretin-related amyloidosis in vivo remain unclear. The abundance of the 49-127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in...
8.
Naqvi M, Heidarsson P, R Otazo M, Mossa A, Kragelund B, Cecconi C
Biophys J
. 2015 Jul;
109(1):113-23.
PMID: 26153708
Neuronal calcium sensor-1 (NCS-1) is the primordial member of a family of proteins responsible primarily for sensing changes in neuronal Ca(2+) concentration. NCS-1 is a multispecific protein interacting with a...
9.
Heidarsson P, Naqvi M, R Otazo M, Mossa A, Kragelund B, Cecconi C
Proc Natl Acad Sci U S A
. 2014 Aug;
111(36):13069-74.
PMID: 25157171
Neurodegenerative disorders are strongly linked to protein misfolding, and crucial to their explication is a detailed understanding of the underlying structural rearrangements and pathways that govern the formation of misfolded...
10.
Mangione P, Esposito G, Relini A, Raimondi S, Porcari R, Giorgetti S, et al.
J Biol Chem
. 2013 Sep;
288(43):30917-30.
PMID: 24014031
Systemic amyloidosis is a fatal disease caused by misfolding of native globular proteins, which then aggregate extracellularly as insoluble fibrils, damaging the structure and function of affected organs. The formation...