Mark B Pepys
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Explore the profile of Mark B Pepys including associated specialties, affiliations and a list of published articles.
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81
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6478
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Recent Articles
1.
Schmidt A, Finan C, Chopade S, Ellmerich S, Rossor M, Hingorani A, et al.
Open Biol
. 2024 Jul;
14(7):230419.
PMID: 39013416
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein,...
2.
Yip P, Liu Z, Hasan S, Pepys M, Uff C
Open Biol
. 2023 Dec;
13(12):230253.
PMID: 38052249
The mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are poorly understood. The normal plasma protein, serum amyloid P component (SAP), which is normally rigorously excluded from the brain,...
3.
Schmidt A, Finan C, Chopade S, Ellmerich S, Rossor M, Hingorani A, et al.
medRxiv
. 2023 Aug;
PMID: 37645746
The direct causes of neurodegeneration underlying Alzheimer's disease (AD) and many other dementias, are not known. Here we identify serum amyloid P component (SAP), a constitutive plasma protein normally excluded...
4.
Slamova I, Adib R, Ellmerich S, Golos M, Gilbertson J, Botcher N, et al.
Nat Commun
. 2021 Dec;
12(1):7112.
PMID: 34876572
Cardiac ATTR amyloidosis, a serious but much under-diagnosed form of cardiomyopathy, is caused by deposition of amyloid fibrils derived from the plasma protein transthyretin (TTR), but its pathogenesis is poorly...
5.
Ellmerich S, Taylor G, Richardson C, Minett T, Schmidt A, Brayne C, et al.
Brain Commun
. 2021 Oct;
3(4):fcab225.
PMID: 34671726
Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer's disease and some other common dementias is not known. The normal human plasma protein, serum...
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Raimondi S, Mangione P, Verona G, Canetti D, Nocerino P, Marchese L, et al.
J Biol Chem
. 2020 Jun;
295(33):11379-11387.
PMID: 32571879
Systemic amyloidosis caused by extracellular deposition of insoluble fibrils derived from the pathological aggregation of circulating proteins, such as transthyretin, is a severe and usually fatal condition. Elucidation of the...
9.
Corazza A, Verona G, Waudby C, Mangione P, Bingham R, Uings I, et al.
J Med Chem
. 2019 Aug;
62(17):8274-8283.
PMID: 31393717
The wild type protein, transthyretin (TTR), and over 120 genetic TTR variants are amyloidogenic and cause, respectively, sporadic and hereditary systemic TTR amyloidosis. The homotetrameric TTR contains two identical thyroxine...
10.
Pepys M
Front Immunol
. 2018 Nov;
9:2382.
PMID: 30459761
The phylogenetically ancient, pentraxin family of plasma proteins, comprises C-reactive protein (CRP) and serum amyloid P component (SAP) in humans and the homologous proteins in other species. They are composed...