Mohammad R Ebrahimkhani
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Explore the profile of Mohammad R Ebrahimkhani including associated specialties, affiliations and a list of published articles.
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20
Citations
751
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Recent Articles
1.
Bigorgne A, John B, Ebrahimkhani M, Shimizu-Albergine M, Campbell J, Crispe I
PLoS One
. 2016 Mar;
11(3):e0151063.
PMID: 27002851
Background & Aims: The gut microbiota significantly influences hepatic immunity. Little is known on the precise mechanism by which liver cells mediate recognition of gut microbes at steady state. Here...
2.
Guye P, Ebrahimkhani M, Kipniss N, Velazquez J, Schoenfeld E, Kiani S, et al.
Nat Commun
. 2016 Jan;
7:10243.
PMID: 26732624
Human induced pluripotent stem cells (hiPSCs) have potential for personalized and regenerative medicine. While most of the methods using these cells have focused on deriving homogenous populations of specialized cells,...
3.
Mohar I, Brempelis K, Murray S, Ebrahimkhani M, Crispe I
Methods Mol Biol
. 2015 Oct;
1325:3-17.
PMID: 26450375
Hepatocytes comprise the majority of liver mass and cell number. However, in order to understand liver biology, the non-parenchymal cells (NPCs) must be considered. Herein, a relatively rapid and efficient...
4.
Kiani S, Chavez A, Tuttle M, Hall R, Chari R, Ter-Ovanesyan D, et al.
Nat Methods
. 2015 Sep;
12(11):1051-4.
PMID: 26344044
We demonstrate that by altering the length of Cas9-associated guide RNA (gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a...
5.
Sarkar U, Rivera-Burgos D, Large E, Hughes D, Ravindra K, Dyer R, et al.
Drug Metab Dispos
. 2015 May;
43(7):1091-9.
PMID: 25926431
Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for investigation of inflammatory effects...
6.
Ebrahimkhani M, Daneshmand A, Mazumder A, Allocca M, Calvo J, Abolhassani N, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(45):E4878-86.
PMID: 25349415
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases...
7.
Kiani S, Beal J, Ebrahimkhani M, Huh J, Hall R, Xie Z, et al.
Nat Methods
. 2014 May;
11(7):723-6.
PMID: 24797424
A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device libraries. Here we present a modular transcriptional repression architecture based on clustered regularly interspaced palindromic...
8.
Ebrahimkhani M, Young C, Lauffenburger D, Griffith L, Borenstein J
Drug Discov Today
. 2014 May;
19(6):754-62.
PMID: 24793141
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments...
9.
Ebrahimkhani M, Neiman J, Raredon M, Hughes D, Griffith L
Adv Drug Deliv Rev
. 2014 Mar;
69-70:132-57.
PMID: 24607703
Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and...
10.
Wheeler S, Borenstein J, Clark A, Ebrahimkhani M, Fox I, Griffith L, et al.
Stem Cell Res Ther
. 2014 Feb;
4 Suppl 1:S11.
PMID: 24565274
The vast majority of cancer mortalities result from distant metastases. The metastatic microenvironment provides unique protection to ectopic tumors as the primary tumors often respond to specific agents. Although significant...