Approaches to in Vitro Tissue Regeneration with Application for Human Disease Modeling and Drug Development

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2014 May 6

PMID 24793141

Citations 18

Authors

Mohammad R Ebrahimkhani

Carissa L Young

Douglas A Lauffenburger

Linda G Griffith

Jeffrey T Borenstein

Affiliations

Soon will be listed here.

Abstract

Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.

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