Mohamad Wessam Alnouri
Overview
Explore the profile of Mohamad Wessam Alnouri including associated specialties, affiliations and a list of published articles.
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9
Citations
184
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Recent Articles
1.
Cho H, Lai C, Bonnavion R, Alnouri M, Wang S, Roquid K, et al.
Science
. 2025 Feb;
387(6734):674-682.
PMID: 39913566
Insulin resistance is a hallmark of obesity-associated type 2 diabetes. Insulin's actions go beyond metabolic cells and also involve blood vessels, where insulin increases capillary blood flow and delivery of...
2.
Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler J, Kaps A, Rajkumar R, et al.
J Med Chem
. 2025 Jan;
68(2):1195-1221.
PMID: 39803894
The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12()-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in...
3.
Jin Y, Liang G, Li R, Wang S, Alnouri M, Bentsen M, et al.
Nat Cardiovasc Res
. 2025 Jan;
4(2):180-196.
PMID: 39779823
Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here...
4.
Alnouri M, Roquid K, Bonnavion R, Cho H, Heering J, Kwon J, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(41):e2407130121.
PMID: 39365815
Inflammation is a protective response to pathogens and injury. To be effective it needs to be resolved by endogenous mechanisms in order to avoid prolonged and excessive inflammation, which can...
5.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov V, Moroz Y, et al.
J Med Chem
. 2024 Jun;
67(13):10567-10588.
PMID: 38917049
G protein-coupled receptor G2A was postulated to be a promising target for the development of new therapeutics in neuropathic pain, acute myeloid leukemia, and inflammation. However, there is still a...
6.
Perniss A, Boonen B, Tonack S, Thiel M, Poharkar K, Alnouri M, et al.
Sci Adv
. 2023 Aug;
9(31):eadg8842.
PMID: 37531421
Host-derived succinate accumulates in the airways during bacterial infection. Here, we show that luminal succinate activates murine tracheal brush (tuft) cells through a signaling cascade involving the succinate receptor 1...
7.
Wedel S, Hahnefeld L, Alnouri M, Offermanns S, Hausch F, Geisslinger G, et al.
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430751
Neuropathic pain is a pathological pain state with a broad symptom scope that affects patients after nerve injuries, but it can also arise after infections or exposure to toxic substances....
8.
Schebb N, Kuhn H, Kahnt A, Rund K, ODonnell V, Flamand N, et al.
Front Pharmacol
. 2022 Mar;
13:838782.
PMID: 35308198
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1,...
9.
Le Mercier A, Bonnavion R, Yu W, Alnouri M, Ramas S, Zhang Y, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33875597
G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in...
10.
Abdelrahman A, Yerande S, Namasivayam V, Klapschinski T, Alnouri M, El-Tayeb A, et al.
Eur J Med Chem
. 2019 Nov;
186:111879.
PMID: 31780082
Adenosine acts as a powerful signaling molecule via four distinct G protein-coupled receptors, designated A, A, A and A adenosine receptors (ARs). A and A ARs are G-coupled, while A...