Dieter Steinhilber
Overview
Explore the profile of Dieter Steinhilber including associated specialties, affiliations and a list of published articles.
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237
Citations
3225
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Recent Articles
1.
Bruckhoff R, Becker O, Steinhilber D, Suess B
ACS Synth Biol
. 2025 Feb;
PMID: 40011207
Synthetic riboswitches are attracting increasing interest for a diverse range of applications, including synthetic biology, functional genomics, and prospective therapeutic strategies. This study demonstrates that controlling alternative splicing with synthetic...
2.
Neb H, Roth V, Roos J, Bauer T, Urbschat A, Heinicke U, et al.
Front Immunol
. 2025 Feb;
15:1148806.
PMID: 39959584
Introduction: Critically ill patients suffer from a wide variety of clinical events, most of them leading to pro-inflammatory states such as sepsis or simply as consequence of major surgery. Many...
3.
Hyprath M, Molitor M, Schweighofer I, Marschalek R, Steinhilber D
Front Pharmacol
. 2025 Jan;
15:1520507.
PMID: 39877387
5-Lipoxygenase (5-LO), encoded by the gene , is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway...
4.
Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler J, Kaps A, Rajkumar R, et al.
J Med Chem
. 2025 Jan;
68(2):1195-1221.
PMID: 39803894
The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12()-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in...
5.
Molitor M, Menge A, Mandel S, George S, Muller S, Knapp S, et al.
Pflugers Arch
. 2024 Sep;
476(12):1913-1928.
PMID: 39347835
Human 5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes, mediators of the innate immune system that also play an important role in inflammatory diseases and cancer. In...
6.
Patrignani P, Contursi A, Tacconelli S, Steinhilber D
Front Pharmacol
. 2024 Sep;
15:1472396.
PMID: 39268466
Many drugs can act on multiple targets or disease pathways, regardless of their original purpose. Drug repurposing involves reevaluating existing compounds for new medical uses. This can include repositioning approved...
7.
Ildefeld N, Steinhilber D, Proschak E, Heering J
iScience
. 2024 Jul;
27(7):110333.
PMID: 39055912
The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the treatment of viruses with pandemic potential. The development of a diverse drug portfolio is therefore crucial for...
8.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov V, Moroz Y, et al.
J Med Chem
. 2024 Jun;
67(13):10567-10588.
PMID: 38917049
G protein-coupled receptor G2A was postulated to be a promising target for the development of new therapeutics in neuropathic pain, acute myeloid leukemia, and inflammation. However, there is still a...
9.
Kahnt A, Hafner A, Steinhilber D
Oncogene
. 2024 Apr;
43(18):1319-1327.
PMID: 38575760
5-Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT) biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune cells, that control inflammatory and allergic responses....
10.
Balzulat A, Zhu W, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(15):e2307237.
PMID: 38350720
Various disorders are accompanied by histamine-independent itching, which is often resistant to the currently available therapies. Here, it is reported that the pharmacological activation of Slack (Kcnt1, K1.1), a potassium...