Mitchell D Miller
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Explore the profile of Mitchell D Miller including associated specialties, affiliations and a list of published articles.
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147
Citations
1735
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Recent Articles
1.
Pan T, Dun C, Jin S, Miller M, Kyrillidis A, Phillips Jr G
Struct Dyn
. 2024 Aug;
11(4):044701.
PMID: 39148510
Determining the atomic-level structure of a protein has been a decades-long challenge. However, recent advances in transformers and related neural network architectures have enabled researchers to significantly improve solutions to...
2.
Cole C, Walker D, Hulgan S, Pogostin B, Swain J, Miller M, et al.
Nat Chem
. 2024 Jul;
16(10):1698-1704.
PMID: 39009792
The most abundant natural collagens form heterotrimeric triple helices. Synthetic mimics of collagen heterotrimers have been found to fold slowly, even compared to the already slow rates of homotrimeric helices....
3.
Burgie E, Mickles A, Luo F, Miller M, Vierstra R
J Biol Chem
. 2024 May;
300(7):107369.
PMID: 38750792
Phytochromes (Phys) are a diverse collection of photoreceptors that regulate numerous physiological and developmental processes in microorganisms and plants through photointerconversion between red-light-absorbing Pr and far-red light-absorbing Pfr states. Light...
4.
Jalali E, Wang F, Overbay B, Miller M, Shaaban K, Ponomareva L, et al.
J Nat Prod
. 2024 Feb;
87(4):798-809.
PMID: 38412432
Structural and functional studies of the carminomycin 4--methyltransferase DnrK are described, with an emphasis on interrogating the acceptor substrate scope of DnrK. Specifically, the evaluation of 100 structurally and functionally...
5.
Alexander L, Durairaj J, Kryshtafovych A, Abriata L, Bayo Y, Bhabha G, et al.
Proteins
. 2023 Jul;
91(12):1571-1599.
PMID: 37493353
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how...
6.
Pan T, Jin S, Miller M, Kyrillidis A, Phillips Jr G
IUCrJ
. 2023 Jul;
10(Pt 4):487-496.
PMID: 37409806
The general de novo solution of the crystallographic phase problem is difficult and only possible under certain conditions. This paper develops an initial pathway to a deep learning neural network...
7.
Liu Z, Rivera S, Newmister S, Sanders J, Nie Q, Liu S, et al.
Nat Chem
. 2023 Jan;
15(4):526-534.
PMID: 36635598
The Diels-Alder cycloaddition is one of the most powerful approaches in organic synthesis and is often used in the synthesis of important pharmaceuticals. Yet, strictly controlling the stereoselectivity of the...
8.
Wu K, Moore J, Miller M, Chen Y, Lee C, Xu W, et al.
Protein Sci
. 2022 Sep;
31(10):e4443.
PMID: 36173166
Genetic code expansion technology allows for the use of noncanonical amino acids (ncAAs) to create semisynthetic organisms for both biochemical and biomedical applications. However, exogenous feeding of chemically synthesized ncAAs...
9.
Traver M, Bradford S, Olmos Jr J, Wright Z, Miller M, Xu W, et al.
Front Cell Dev Biol
. 2022 Mar;
10:838923.
PMID: 35300425
Peroxisomes are eukaryotic organelles that sequester critical oxidative reactions and process the resulting reactive oxygen species into less toxic byproducts. Peroxisome function and formation are coordinated by peroxins (PEX proteins)...
10.
Kosgei A, Miller M, Bhardwaj M, Xu W, Thorson J, Van Lanen S, et al.
Acta Crystallogr F Struct Biol Commun
. 2022 Jan;
78(Pt 1):1-7.
PMID: 34981769
Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster...