Mitchell Cheung
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Explore the profile of Mitchell Cheung including associated specialties, affiliations and a list of published articles.
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31
Citations
1696
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Recent Articles
1.
Menges C, Hassan D, Cheung M, Bellacosa A, Testa J
Curr Top Microbiol Immunol
. 2024 Aug;
PMID: 39192048
The AKT kinases are critical signaling molecules that regulate cellular physiology upon the activation of tyrosine kinase receptors and phosphatidylinositol 3-kinases (PI3K). AKT kinases govern many cellular processes considered hallmarks...
2.
Kadariya Y, Sementino E, Ruan M, Cheung M, Hadikhani P, Osmanbeyoglu H, et al.
Cancer Res Commun
. 2024 Apr;
4(4):1004-1015.
PMID: 38592450
Significance: We show that germline Bap1-mutant mice have enhanced susceptibility to MM upon minimal exposure to chrysotile asbestos, not only amphibole fibers. Chrysotile induced a more profound immune tumor response...
3.
Sementino E, Kadariya Y, Cheung M, Menges C, Tan Y, Kukuyan A, et al.
Mol Cancer Res
. 2022 Jan;
20(5):699-711.
PMID: 35082167
Implications: We provide evidence supporting a role for PAK inhibitors in treating NF2-deficient tumors. NF2-deficient tumors lacking Pak2 eventually adapt by kinome reprogramming, presenting opportunities for combination therapies to bypass...
4.
Cheung M, Kadariya Y, Sementino E, Hall M, Cozzi I, Ascoli V, et al.
Hum Mol Genet
. 2021 May;
30(18):1750-1761.
PMID: 34008015
There is irrefutable evidence that germline BRCA1-associated protein 1 gene (BAP1) mutations contribute to malignant mesothelioma (MM) susceptibility. However, BAP1 mutations are not found in all cases with evidence of...
5.
Peng H, Cassel J, McCracken D, Prokop J, Sementino E, Cheung M, et al.
Mol Cancer Res
. 2021 Mar;
19(7):1099-1112.
PMID: 33731362
BAP1 is an ubiquitin hydrolase whose deubiquitinase activity is mediated by polycomb group-like protein ASXL2. Cancer-related mutations/deletions lead to loss-of-function by targeting the catalytic ubiquitin C-terminal hydrolase (UCH) or UCH37-like...
6.
Tan Y, Sementino E, Cheung M, Peri S, Menges C, Kukuyan A, et al.
Clin Cancer Res
. 2020 Nov;
27(4):1200-1213.
PMID: 33203643
Purpose: Receptor-interacting protein kinase 3 (RIPK3) phosphorylates effector molecule MLKL to trigger necroptosis. Although RIPK3 loss is seen in several human cancers, its role in malignant mesothelioma is unknown. This...
7.
Kukuyan A, Sementino E, Kadariya Y, Menges C, Cheung M, Tan Y, et al.
Cancer Res
. 2019 Jun;
79(16):4113-4123.
PMID: 31151962
Pleural malignant mesothelioma is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of , and are the most frequent genetic lesions in human malignant mesothelioma. We...
8.
Walpole S, Pritchard A, Cebulla C, Pilarski R, Stautberg M, Davidorf F, et al.
J Natl Cancer Inst
. 2018 Dec;
110(12):1328-1341.
PMID: 30517737
Background: The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 encoding a tumor suppressor associated with uveal melanoma, mesothelioma,...
9.
Peng H, Prokop J, Karar J, Park K, Cao L, Harbour J, et al.
Cancer Res
. 2017 Dec;
78(5):1200-1213.
PMID: 29284740
Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However,...
10.
Cheung M, Testa J
Transl Lung Cancer Res
. 2017 Jul;
6(3):270-278.
PMID: 28713672
Like cancer generally, malignant mesothelioma (MM) is a genetic disease at the cellular level. DNA copy number analysis of mesothelioma specimens has revealed a number of recurrent sites of chromosomal...