Ming Tse
Overview
Explore the profile of Ming Tse including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
376
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Recent Articles
1.
Rong Y, Zhang Z, De Jonge H, Lin R, Yu H, Sarker R, et al.
bioRxiv
. 2025 Feb;
PMID: 39975121
Constipation causes significant morbidity in Cystic Fibrosis (CF) patients. Using CF patient (F508del) derived ileal and distal colonic/rectal enteroids as a model and the Forskolin Induced Swelling Assay (FIS), we...
2.
Chu T, Yottasan P, de Souza Goncalves L, Oak A, Lin R, Tse M, et al.
Transl Res
. 2023 Sep;
263:45-52.
PMID: 37678755
Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea treatment is primarily supportive, and oral...
3.
Singh V, Yang J, Yin J, Cole R, Tse M, Berman D, et al.
J Cell Sci
. 2018 Jul;
131(16).
PMID: 30030371
Cholera toxin (CT) causes severe diarrhea by increasing intracellular cAMP leading to a PKA-dependent increase in Cl secretion through CFTR and decreased Na absorption through inhibition of Na/H exchanger 3...
4.
Cil O, Phuan P, Gillespie A, Lee S, Tradtrantip L, Yin J, et al.
FASEB J
. 2016 Nov;
31(2):751-760.
PMID: 27871064
Secretory diarrheas caused by bacterial enterotoxins, including cholera and traveler's diarrhea, remain a major global health problem. Inappropriate activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel occurs...
5.
Singh V, Yang J, Cha B, Chen T, Sarker R, Yin J, et al.
Mol Biol Cell
. 2015 Apr;
26(11):2030-43.
PMID: 25851603
Sorting nexin 27 (SNX27) contains a PDZ domain that is phylogenetically related to the PDZ domains of the NHERF proteins. Studies on nonepithelial cells have shown that this protein is...
6.
Conklin L, Cuffari C, Okazaki T, Miao Y, Saatian B, Chen T, et al.
J Dig Dis
. 2012 Jan;
13(2):82-93.
PMID: 22257476
Objective: 6-mercaptopurine (6-MP) is efficacious in the treatment of inflammatory bowel disease (IBD). However, about one-third of patients respond poorly to therapy. This study aimed to characterize the inherent differences...
7.
Cha B, Zhu X, Chen W, Jones M, Ryoo S, Zachos N, et al.
J Cell Sci
. 2010 Jun;
123(Pt 14):2434-43.
PMID: 20571054
The epithelial brush border (BB) Na(+)/H(+) exchanger NHE3 is associated with the actin cytoskeleton by binding both directly and indirectly to ezrin; indirect binding is via attachment to NHERF family...
8.
Lin S, Yeruva S, He P, Singh A, Zhang H, Chen M, et al.
Gastroenterology
. 2009 Oct;
138(2):649-58.
PMID: 19800338
Background & Aims: Diarrhea results from reduced net fluid and salt absorption caused by an imbalance in intestinal absorption and secretion. The bulk of sodium and water absorption in the...
9.
Cha B, Tse M, Yun C, Kovbasnjuk O, Mohan S, Hubbard A, et al.
Mol Biol Cell
. 2006 Mar;
17(6):2661-73.
PMID: 16540524
Based on physiological studies, the epithelial brush-border (BB) Na+/H+ antiporter3 (NHE3) seems to associate with the actin cytoskeleton both by binding to and independently of the PDZ domain containing proteins...
10.
Zachos N, Tse M, Donowitz M
Annu Rev Physiol
. 2005 Feb;
67:411-43.
PMID: 15709964
The sodium/hydrogen exchange (NHE) gene family plays an integral role in neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of nine members that are categorized...