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Milankumar Patel

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Articles 13
Citations 751
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Recent Articles
1.
Patel M, Panja S, Zaman L, Yeapuri P, Bhattarai S, Gorantla S, et al.
Nat Commun . 2025 Jan; 16(1):513. PMID: 39779664
Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise,...
2.
Gendelman H, Patel M, Panja S, Zaman L, Yeapuri P, Bhattarai S, et al.
Res Sq . 2024 Jun; PMID: 38883780
Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise,...
3.
Yeapuri P, Machhi J, Lu Y, Abdelmoaty M, Kadry R, Patel M, et al.
Mol Neurodegener . 2023 Dec; 18(1):97. PMID: 38111016
Background: Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegenerative...
4.
Shahjin F, Patel M, Machhi J, Cohen J, Nayan M, Yeapuri P, et al.
Acta Biomater . 2022 Dec; 158:493-509. PMID: 36581007
Effective antigen delivery facilitates antiviral vaccine success defined by effective immune protective responses against viral exposures. To improve severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigen delivery, a controlled biodegradable, stable,...
5.
Shahjin F, Patel M, Hasan M, Cohen J, Islam F, Ashaduzzaman M, et al.
Nanomedicine . 2022 Dec; 48:102644. PMID: 36549555
Porous polymer microspheres are employed in biotherapeutics, tissue engineering, and regenerative medicine. Porosity dictates cargo carriage and release that are aligned with the polymer physicochemical properties. These include material tuning,...
6.
Machhi J, Yeapuri P, Markovic M, Patel M, Yan W, Lu Y, et al.
ACS Chem Neurosci . 2022 Mar; 13(8):1232-1244. PMID: 35312284
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Pathologically, the disease is characterized by the deposition of amyloid beta (Aβ) plaques and the presence of neurofibrillary tangles. These drive...
7.
Herskovitz J, Hasan M, Patel M, Kevadiya B, Gendelman H
Methods Mol Biol . 2022 Jan; 2407:429-445. PMID: 34985679
First identified as a viral defense mechanism, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) has been transformed into a gene-editing tool. It now affords promise in...
8.
Herskovitz J, Hasan M, Patel M, Blomberg W, Cohen J, Machhi J, et al.
EBioMedicine . 2021 Nov; 73:103678. PMID: 34774454
Background: A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent...
9.
Patel M, Shahjin F, Cohen J, Hasan M, Machhi J, Chugh H, et al.
FEMS Microbiol Rev . 2021 Jun; 45(6). PMID: 34160586
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to coronavirus disease 2019 (COVID-19). Virus-specific immunity controls infection, transmission and disease severity. With respect to disease severity, a...
10.
Kevadiya B, Machhi J, Herskovitz J, Oleynikov M, Blomberg W, Bajwa N, et al.
Nat Mater . 2021 Feb; 20(5):593-605. PMID: 33589798
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat,...