Mike O Karl
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Explore the profile of Mike O Karl including associated specialties, affiliations and a list of published articles.
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39
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1489
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Recent Articles
1.
Wagner F, Karl M
Adv Exp Med Biol
. 2025 Feb;
1468:383-387.
PMID: 39930226
Neurodegenerative diseases involve many different (sub)cellular pathologic processes like mitochondria damage, which are still incompletely understood and present future targets for therapy development. Live imaging microscopy of dynamic pathologic changes...
2.
Carido M, Volkner M, Steinheuer L, Wagner F, Kurth T, Dumler N, et al.
Front Cell Neurosci
. 2023 Oct;
17:1166641.
PMID: 37868194
The possible applications for human retinal organoids (HROs) derived from human induced pluripotent stem cells (hiPSC) rely on the robustness and transferability of the methodology for their generation. Standardized strategies...
3.
Volkner M, Wagner F, Kurth T, Sykes A, Del Toro Runzer C, Ebner L, et al.
Front Cell Neurosci
. 2023 May;
17:1106287.
PMID: 37213216
Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research. However, to which extent differential neuronal and glial pathologic processes can...
4.
Volkner M, Wagner F, Steinheuer L, Carido M, Kurth T, Yazbeck A, et al.
Nat Commun
. 2022 Oct;
13(1):6183.
PMID: 36261438
Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness. Here, we establish a human retinal organoid system reproducing several...
5.
Gasparini S, Tessmer K, Reh M, Wieneke S, Carido M, Volkner M, et al.
J Clin Invest
. 2022 Apr;
132(12).
PMID: 35482419
Once human photoreceptors die, they do not regenerate, thus, photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation, and synaptic...
6.
Heisterkamp P, Borsch O, Lezama N, Gasparini S, Fathima A, Carvalho L, et al.
Exp Eye Res
. 2022 Mar;
219:109033.
PMID: 35288107
Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this...
7.
Volkner M, Kurth T, Schor J, Ebner L, Bardtke L, Kavak C, et al.
Front Cell Dev Biol
. 2021 May;
9:645704.
PMID: 33996806
Using retinal organoid systems, organ-like 3D tissues, relies implicitly on their robustness. However, essential key parameters, particularly retinal growth and longer-term culture, are still insufficiently defined. Here, we hypothesize that...
8.
Volkner M, Pavlou M, Buning H, Michalakis S, Karl M
Hum Gene Ther
. 2021 Mar;
32(13-14):694-706.
PMID: 33752467
The most widely used vectors for gene delivery in the retina are recombinant adeno-associated virus (rAAV) vectors. They have proven to be safe and effective in retinal gene therapy studies...
9.
Schreiter S, Vafia K, Barsacchi R, Tsang S, Bickle M, Ader M, et al.
Stem Cell Reports
. 2020 Nov;
15(6):1347-1361.
PMID: 33242397
Phagocytosis is a key function in various cells throughout the body. A deficiency in photoreceptor outer segment (POS) phagocytosis by the retinal pigment epithelium (RPE) causes vision loss in inherited...
10.
Almedawar S, Vafia K, Schreiter S, Neumann K, Khattak S, Kurth T, et al.
Stem Cell Reports
. 2020 Mar;
14(3):374-389.
PMID: 32160519
Maintenance of a healthy photoreceptor-retinal pigment epithelium (RPE) interface is essential for vision. At the center of this interface, apical membrane protrusions stemming from the RPE ensheath photoreceptor outer segments...