Noritaka Kagaya
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Explore the profile of Noritaka Kagaya including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
235
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Recent Articles
1.
Kojima Y, Fujieda S, Zhou L, Takikawa M, Kuramochi K, Furuya T, et al.
Cancer Sci
. 2024 Jul;
115(9):3054-3066.
PMID: 39009033
Austocystin D is a natural compound that induces cytochrome P450 (CYP) monooxygenase-dependent DNA damage and growth inhibition in certain cancer cell lines. Cancer cells exhibiting higher sensitivity to austocystin D...
2.
Nishimura T, Kudo K, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, et al.
Chem Pharm Bull (Tokyo)
. 2024 May;
72(5):475-479.
PMID: 38749722
Heterologous expression of natural compound biosynthetic gene clusters (BGCs) is a robust approach for not only revealing the biosynthetic mechanisms leading to the compounds, but also for discovering new products...
3.
Song X, Nihashi Y, Imai Y, Mori N, Kagaya N, Suenaga H, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612551
Pancreatic ductal adenocarcinoma (PDAC) is a solid-tumor malignancy. To enhance the treatment landscape of PDAC, a 3D model optimized for rigorous drug screening is essential. Within the PDAC tumor microenvironment,...
4.
Suzuki S, Saito S, Narushima Y, Kodani S, Kagaya N, Suenaga H, et al.
J Antibiot (Tokyo)
. 2023 Nov;
77(1):30-38.
PMID: 37938761
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F (1) and G (2), and cyclopiazonic acid (CPA) (3) as Notch...
5.
Miyashita K, Yagi T, Kagaya N, Takechi A, Nakata C, Kanda R, et al.
Cancer Sci
. 2023 Jul;
114(10):4032-4040.
PMID: 37522388
T-cell acute lymphoblastic leukemia (T-ALL) is one of the most frequently occurring cancers in children and is associated with a poor prognosis. Here, we performed large-scale screening of natural compound...
6.
Choirunnisa A, Arima K, Abe Y, Kagaya N, Kudo K, Suenaga H, et al.
Beilstein J Org Chem
. 2022 Sep;
18:1017-1025.
PMID: 36051562
Only a few azoxy natural products have been identified despite their intriguing biological activities. Azodyrecins D-G, four new analogs of aliphatic azoxides, were identified from two species by a reactivity-based...
7.
Suenaga H, Kagaya N, Kawada M, Tatsuda D, Sato T, Shin-Ya K
J Antibiot (Tokyo)
. 2021 Jul;
74(10):660-666.
PMID: 34326483
Recent progress in three-dimensional (3D) cell culture systems has attracted much attention in the fields of basic life science and drug development. Newly established methods include 3D co-culture, spheroid culture,...
8.
Nishimura T, Kawahara T, Kagaya N, Ogura Y, Takikawa H, Suenaga H, et al.
Org Lett
. 2021 May;
23(11):4415-4419.
PMID: 34029112
We discovered JBIR-155 as a novel specific class D β-lactamase inhibitor from SoB100815Hv02. JBIR-155 consists of a 6-oxabicyclo[3.2.0]heptan-7-one skeleton and a long unsaturated alkyl chain moiety of which absolute configuration...
9.
Kudo K, Nishimura T, Kozone I, Hashimoto J, Kagaya N, Suenaga H, et al.
Sci Rep
. 2021 May;
11(1):9944.
PMID: 33976244
Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular...
10.
Ueoka R, Hashimoto J, Kozone I, Hashimoto T, Kudo K, Kagaya N, et al.
Biosci Biotechnol Biochem
. 2021 Feb;
85(4):890-894.
PMID: 33590846
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by...