Miguel R Branco
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Explore the profile of Miguel R Branco including associated specialties, affiliations and a list of published articles.
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51
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4077
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Recent Articles
1.
Vasconcelos S, Moustakas I, Branco M, Guimaraes S, Canicais C, Helm T, et al.
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791219
The trophoblast cells are responsible for the transfer of nutrients between the mother and the foetus and play a major role in placental endocrine function by producing and releasing large...
2.
Cheng K, Frost J, Sanchez-Luque F, Garcia-Canadas M, Taylor D, Yang W, et al.
Epigenetics Chromatin
. 2023 Oct;
16(1):39.
PMID: 37845773
Background: Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the efficiency...
3.
Pezic D, Weeks S, Varsally W, Dewari P, Pollard S, Branco M, et al.
Stem Cell Reports
. 2023 Oct;
18(11):2154-2173.
PMID: 37802073
Our understanding of how STAG proteins contribute to cell identity and disease have largely been studied from the perspective of chromosome topology and protein-coding gene expression. Here, we show that...
4.
Senner C, Dong Z, Prater M, Branco M, Watson E
Front Cell Dev Biol
. 2023 Jul;
11:1209928.
PMID: 37440923
One-carbon metabolism, including the folate cycle, has a crucial role in fetal development though its molecular function is complex and unclear. The hypomorphic allele is known to disrupt one-carbon metabolism,...
5.
Pal D, Patel M, Boulet F, Sundarraj J, Grant O, Branco M, et al.
Nat Struct Mol Biol
. 2023 Jun;
30(7):935-947.
PMID: 37308596
Mammalian genomes harbor abundant transposable elements (TEs) and their remnants, with numerous epigenetic repression mechanisms enacted to silence TE transcription. However, TEs are upregulated during early development, neuronal lineage, and...
6.
Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(4):527-538.
PMID: 37012406
The placenta is a fast-evolving organ with large morphological and histological differences across eutherians, but the genetic changes driving placental evolution have not been fully elucidated. Transposable elements, through their...
7.
Taylor D, Branco M
Methods Mol Biol
. 2022 Nov;
2607:199-214.
PMID: 36449165
Alignment of short-read sequencing data to interspersed genomic repeats, such as transposable elements, can be problematic. This is especially true for evolutionarily young elements, which have not sufficiently diverged from...
8.
Ashley B, Simner C, Manousopoulou A, Jenkinson C, Hey F, Frost J, et al.
Elife
. 2022 Mar;
11.
PMID: 35256050
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating...
9.
Taylor D, Lowe R, Philippe C, Cheng K, Grant O, Zabet N, et al.
Nucleic Acids Res
. 2021 Dec;
50(6):e33.
PMID: 34908129
Despite a vast expansion in the availability of epigenomic data, our knowledge of the chromatin landscape at interspersed repeats remains highly limited by difficulties in mapping short-read sequencing data to...
10.
Pedraza-Arevalo S, Ibanez-Costa A, Blazquez-Encinas R, Branco M, Vazquez-Borrego M, Herrera-Martinez A, et al.
Mol Oncol
. 2021 Oct;
16(3):764-779.
PMID: 34601790
Somatostatin receptor subtype 5 (SST ) is an emerging biomarker and actionable target in pituitary (PitNETs) and pancreatic (PanNETs) neuroendocrine tumors. Transcriptional and epigenetic regulation of SSTR5 gene expression and...