Miguel A Lasuncion
Overview
Explore the profile of Miguel A Lasuncion including associated specialties, affiliations and a list of published articles.
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70
Citations
1377
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Recent Articles
1.
Molina Y, Garcia-Seisdedos D, Babiy B, Lerma M, Martinez-Botas J, Casarejos M, et al.
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740338
Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle...
2.
Abuobeid R, Sanchez-Marco J, Felices M, Arnal C, Burillo J, Lasheras R, et al.
Int J Mol Sci
. 2022 Apr;
23(8).
PMID: 35456988
Squalene is a natural bioactive triterpene and an important intermediate in the biosynthesis of sterols. To assess the effect of this compound on the hepatic transcriptome, RNA-sequencing was carried out...
3.
Goedeke L, Canfran-Duque A, Rotllan N, Chaube B, Thompson B, Lee R, et al.
Nat Commun
. 2021 Nov;
12(1):6448.
PMID: 34750386
Intricate regulatory networks govern the net balance of cholesterol biosynthesis, uptake and efflux; however, the mechanisms surrounding cholesterol homeostasis remain incompletely understood. Here, we develop an integrative genomic strategy to...
4.
Martinez-Beamonte R, Sanchez-Marco J, Felices M, Barranquero C, Gascon S, Arnal C, et al.
Food Funct
. 2021 Jul;
12(17):8141-8153.
PMID: 34291245
To evaluate the effects of squalene, the main unsaponifiable component of virgin olive oil, on lipid metabolism, two groups of male New Zealand rabbits were fed a 1% sunflower oil-enriched...
5.
Fernandez-Suarez M, Daimiel L, Villa-Turegano G, Pavon M, Busto R, Escola-Gil J, et al.
Biomed Pharmacother
. 2021 Jul;
141:111871.
PMID: 34225017
Selective estrogen receptor modulators (SERMs) are nonsteroidal drugs that display an estrogen-agonist or estrogen-antagonist effect depending on the tissue targeted. SERMs have attracted great clinical interest for the treatment of...
6.
Lasuncion M, Martinez-Botas J, Martin-Sanchez C, Busto R, Gomez-Coronado D
Biochem Pharmacol
. 2021 May;
196:114623.
PMID: 34052188
The mevalonate pathway is responsible for the synthesis of isoprenoids, including sterols and other metabolites that are essential for diverse biological functions. Cholesterol, the main sterol in mammals, and non-sterol...
7.
Canfran-Duque A, Pastor O, Garcia-Seisdedos D, Molina Y, Babiy B, Lerma M, et al.
Int J Mol Sci
. 2021 Apr;
22(8).
PMID: 33920193
Atypical or second-generation antipsychotics are used in the treatment of psychosis and behavioral problems in older persons with dementia. However, these pharmaceutical drugs are associated with an increased risk of...
8.
Gomez-Coronado D, Lasuncion M, Martinez-Botas J, Fernandez-Suarez M
Semin Cancer Biol
. 2020 Sep;
73:101-115.
PMID: 32931953
Selective estrogen receptor modulators (SERMs) are a class of compounds that bind to estrogen receptors (ERs) and possess estrogen agonist or antagonist actions in different tissues. As such, they are...
9.
Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos L, Guillen N, Arnal C, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 Aug;
1865(12):158790.
PMID: 32771460
Background And Aims: The molecular mechanisms by which the liver develops steatotic disease still remain unclear. Previous studies using nutritional and genetic models of hepatic steatosis in mice showed that...
10.
Gomez-Martin J, Aracil E, Insenser M, de la Pena G, Lasuncion M, Galindo J, et al.
Obes Facts
. 2020 May;
13(3):321-330.
PMID: 32388504
Background/aim: Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and amyloid-β(1-40) (Aβ40) emerged as markers of cardiovascular risk because of their actions in the endothelium and their role in...