Mieke Geens
Overview
Explore the profile of Mieke Geens including associated specialties, affiliations and a list of published articles.
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25
Citations
521
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Recent Articles
1.
Dziedzicka D, Tewary M, Keller A, Tilleman L, Prochazka L, Ostblom J, et al.
Sci Rep
. 2021 Mar;
11(1):6137.
PMID: 33731744
Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell...
2.
Tewary M, Dziedzicka D, Ostblom J, Prochazka L, Shakiba N, Heydari T, et al.
PLoS Biol
. 2019 Oct;
17(10):e3000081.
PMID: 31634368
In vitro models of postimplantation human development are valuable to the fields of regenerative medicine and developmental biology. Here, we report characterization of a robust in vitro platform that enabled...
3.
Keller A, Tilleman L, Dziedzicka D, Zambelli F, Sermon K, Van Nieuwerburgh F, et al.
Sci Rep
. 2019 Oct;
9(1):14844.
PMID: 31619727
Human pluripotent stem cells (hPSCs) have significant levels of low-grade genetic mosaicism, which commonly used techniques fail to detect in bulk DNA. These copy number variations remain a hurdle for...
4.
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al.
Stem Cell Reports
. 2018 Jun;
11(1):102-114.
PMID: 29910126
In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed...
5.
Keller A, Dziedzicka D, Zambelli F, Markouli C, Sermon K, Spits C, et al.
Hum Reprod Update
. 2018 Jan;
24(2):162-175.
PMID: 29377992
Background: Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer...
6.
Geens M, Chuva de Sousa Lopes S
Hum Reprod Update
. 2017 Jun;
23(5):520-532.
PMID: 28582519
Background: Human pluripotent stem cells (hPSC), both embryonic and induced (hESC and hiPSC), are regarded as a valuable in vitro model for early human development. In order to fulfil this...
7.
Dziedzicka D, Markouli C, Barbe L, Spits C, Sermon K, Geens M
Stem Cell Rev Rep
. 2016 Aug;
12(6):721-730.
PMID: 27544201
When aiming for homogenous embryoid body (EB) differentiation, the use of equal-sized EBs is required to avoid a size-induced differentiation bias. In this study we developed an efficient and standardized...
8.
Jacobs K, Zambelli F, Mertzanidou A, Smolders I, Geens M, Nguyen H, et al.
Stem Cell Reports
. 2016 Mar;
6(3):330-41.
PMID: 26923824
Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate...
9.
de la Kethulle de Ryhove L, Ansseau E, Nachtegael C, Pieters K, Vanderplanck C, Geens M, et al.
Stem Cells Dev
. 2015 Jul;
24(22):2674-86.
PMID: 26192274
Facioscapulohumeral muscular dystrophy (FSHD) is associated with an activation of the double homeobox 4 (DUX4) gene, which we previously identified within the D4Z4 repeated elements in the 4q35 subtelomeric region....
10.
Welling M, Chen H, Munoz J, Musheev M, Kester L, Junker J, et al.
EMBO Rep
. 2015 Jun;
16(7):791-802.
PMID: 26077710
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. Addition of inhibitors of GSK3β and MEK...