Claudia Spits
Overview
Explore the profile of Claudia Spits including associated specialties, affiliations and a list of published articles.
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44
Citations
1036
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Recent Articles
1.
Lei Y, Duong M, Krivec N, Janssens C, Regin M, Huyghebaert A, et al.
Cell Prolif
. 2025 Feb;
:e13813.
PMID: 39908990
Chromosomal abnormalities acquired during cell culture can compromise the differentiation potential of human pluripotent stem cells (hPSCs). In this work, we identified a diminished differentiation capacity to retinal progenitor cells...
2.
Van Der Kelen A, Li Piani L, Mertens J, Regin M, Couvreu de Deckersberg E, Van de Velde H, et al.
Hum Reprod Open
. 2025 Jan;
2025(1):hoae074.
PMID: 39830711
Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically...
3.
Regin M, Lei Y, Couvreu de Deckersberg E, Janssens C, Huyghebaert A, Guns Y, et al.
Elife
. 2024 Dec;
12.
PMID: 39652462
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies...
4.
Krivec N, Couvreu de Deckersberg E, Lei Y, Al Delbany D, Regin M, Verhulst S, et al.
Cell Death Dis
. 2024 Nov;
15(11):852.
PMID: 39572522
Gain of 1q is a highly recurrent chromosomal abnormality in human pluripotent stem cells. In this work, we show that gains of 1q impact the differentiation capacity to derivates of...
5.
The Additive Effect of Combinations of FSH Receptor Gene Variants in Ovarian Response to Stimulation
Neves A, Garcia S, Vuong L, Blockeel C, Spits C, Polyzos N
Reprod Sci
. 2024 Sep;
31(11):3560-3568.
PMID: 39322797
To analyze whether combinations of polymorphisms within FSHR gene influence ovarian response (OR) to stimulation. A multicenter prospective cohort study was conducted from 11/2016-06/2019 in Europe and Asia including predicted...
6.
Al Delbany D, Ghosh M, Krivec N, Huyghebaert A, Regin M, Duong M, et al.
Cells
. 2024 Aug;
13(16).
PMID: 39195283
Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study...
7.
Lei Y, Al Delbany D, Krivec N, Regin M, Couvreu de Deckersberg E, Janssens C, et al.
Stem Cell Reports
. 2024 Mar;
19(4):562-578.
PMID: 38552632
Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, because cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent...
8.
Mertens J, Belva F, van Montfoort A, Regin M, Zambelli F, Seneca S, et al.
Nat Commun
. 2024 Feb;
15(1):1232.
PMID: 38336715
Children conceived through assisted reproductive technologies (ART) have an elevated risk of lower birthweight, yet the underlying cause remains unclear. Our study explores mitochondrial DNA (mtDNA) variants as contributors to...
9.
Krivec N, Ghosh M, Spits C
Stem Cell Reports
. 2023 Dec;
19(1):11-27.
PMID: 38157850
The genetic abnormalities observed in hPSC cultures worldwide have been suggested to pose an important hurdle in their safe use in regenerative medicine due to the possibility of oncogenic transformation...
10.
Ludwig T, Andrews P, Barbaric I, Benvenisty N, Bhattacharyya A, Crook J, et al.
Stem Cell Reports
. 2023 Sep;
18(9):1744-1752.
PMID: 37703820
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research...