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Christina Markouli

Explore the profile of Christina Markouli including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 65
Followers 0
Related Specialties
Cell Biology
Molecular Biology
Reproductive Medicine
Top 10 Co-Authors
Claudia Spits
Karen Sermon
Mieke Geens
Dominika Dziedzicka
Alexander Keller
Lise Barbe
Silvie Franck
Edouard Couvreu de Deckersberg
Filippo Zambelli
Mukul Tewary
Published In
Mol Hum Reprod
Stem Cell Reports
Methods Mol Biol
Stem Cell Rev Rep
Sci Rep
Affiliations
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Recent Articles
1.
Measuring Early Germ-Layer Specification Bias in Human Pluripotent Stem Cells
Keller A, Krivec N, Markouli C, Spits C
Methods Mol Biol . 2022 May; 2429:57-72. PMID: 35507155
Human pluripotent stem cells have a wide variety of potential applications, ranging from clinical translation to in vitro disease modeling. However, there is significant variation in the potential of individual...
2.
Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing
Franck S, Couvreu de Deckersberg E, Bubenik J, Markouli C, Barbe L, Allemeersch J, et al.
Biol Open . 2022 Jan; 11(1). PMID: 35019138
Skeletal muscle tissue is severely affected in myotonic dystrophy type 1 (DM1) patients, characterised by muscle weakness, myotonia and muscle immaturity in the most severe congenital form of the disease....
3.
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm
Dziedzicka D, Tewary M, Keller A, Tilleman L, Prochazka L, Ostblom J, et al.
Sci Rep . 2021 Mar; 11(1):6137. PMID: 33731744
Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell...
4.
Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al.
Stem Cell Reports . 2018 Jun; 11(1):102-114. PMID: 29910126
In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed...
5.
Genetic and epigenetic factors which modulate differentiation propensity in human pluripotent stem cells
Keller A, Dziedzicka D, Zambelli F, Markouli C, Sermon K, Spits C, et al.
Hum Reprod Update . 2018 Jan; 24(2):162-175. PMID: 29377992
Background: Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer...
6.
A High Proliferation Rate is Critical for Reproducible and Standardized Embryoid Body Formation from Laminin-521-Based Human Pluripotent Stem Cell Cultures
Dziedzicka D, Markouli C, Barbe L, Spits C, Sermon K, Geens M
Stem Cell Rev Rep . 2016 Aug; 12(6):721-730. PMID: 27544201
When aiming for homogenous embryoid body (EB) differentiation, the use of equal-sized EBs is required to avoid a size-induced differentiation bias. In this study we developed an efficient and standardized...
7.
Human embryonic stem cells show low-grade microsatellite instability
Nguyen H, Markouli C, Geens M, Barbe L, Sermon K, Spits C
Mol Hum Reprod . 2014 Aug; 20(10):981-9. PMID: 25082980
It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem...