Michelle Debatisse
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Explore the profile of Michelle Debatisse including associated specialties, affiliations and a list of published articles.
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51
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2459
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Recent Articles
1.
Ghilain C, Vidal-Cruchez O, Joly A, Debatisse M, Gilson E, Giraud-Panis M
Cells
. 2024 Aug;
13(16).
PMID: 39195250
Linear unconstrained DNA cannot harbor supercoils since these supercoils can diffuse and be eliminated by free rotation of the DNA strands at the end of the molecule. Mammalian telomeres, despite...
2.
Matos-Rodrigues G, Barroca V, Muhammad A, Dardillac E, Allouch A, Koundrioukoff S, et al.
EMBO J
. 2023 Sep;
42(20):e110844.
PMID: 37661798
Homologous recombination (HR) is a prominent DNA repair pathway maintaining genome integrity. Mutations in many HR genes lead to cancer predisposition. Paradoxically, the implication of the pivotal HR factor RAD51...
3.
Kim S, Maric C, Briu L, Fauchereau F, Baldacci G, Debatisse M, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445805
Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce...
4.
Brison O, Gnan S, Azar D, Koundrioukoff S, Melendez-Garcia R, Kim S, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(4):539-550.
PMID: 37024657
Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which delays mitotic onset. Under-replication of common fragile sites...
5.
Bauwens S, Lototska L, Koundrioukoff S, Debatisse M, Ye J, Gilson E, et al.
Life (Basel)
. 2021 Apr;
11(4).
PMID: 33804994
Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication through pericentromeric heterochromatin requires...
6.
Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nahse V, et al.
Nat Commun
. 2019 Dec;
10(1):5693.
PMID: 31836700
Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription...
7.
Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, et al.
PLoS One
. 2019 Mar;
14(3):e0213383.
PMID: 30840704
Replicative DNA polymerases are frequently stalled at damaged template strands. Stalled replication forks are restored by the DNA damage tolerance (DDT) pathways, error-prone translesion DNA synthesis (TLS) to cope with...
8.
Blin M, Le Tallec B, Nahse V, Schmidt M, Brossas C, Millot G, et al.
Nat Struct Mol Biol
. 2019 Jan;
26(1):58-66.
PMID: 30598553
Common fragile sites (CFSs) are loci that are hypersensitive to replication stress and hotspots for chromosomal rearrangements in cancers. CFSs replicate late in S phase, are cell-type specific and nest...
9.
Debatisse M, Rosselli F
Genes Chromosomes Cancer
. 2018 Nov;
58(5):305-316.
PMID: 30387289
Some regions of the genome, notably common fragile sites (CFSs), are hypersensitive to replication stress and often involved in the generation of gross chromosome rearrangements in cancer cells. CFSs nest...
10.
Mendez-Bermudez A, Lototska L, Bauwens S, Giraud-Panis M, Croce O, Jamet K, et al.
Mol Cell
. 2018 May;
70(3):449-461.e5.
PMID: 29727617
Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the event of replication stress, to chromosome fragility, aging, and cancer. Our knowledge of...