Anne-Marie Lachages
Overview
Explore the profile of Anne-Marie Lachages including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
449
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0
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Recent Articles
1.
Brison O, Gnan S, Azar D, Koundrioukoff S, Melendez-Garcia R, Kim S, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(4):539-550.
PMID: 37024657
Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which delays mitotic onset. Under-replication of common fragile sites...
2.
Arruda D, Lachages A, Demory H, Escriou G, Lai-Kuen R, Dugas P, et al.
J Control Release
. 2022 Aug;
350:228-243.
PMID: 35995297
Vectorized small interfering RNAs (siRNAs) are widely used to induce gene silencing. Among the delivery systems used, lipid-based particles are the most effective. Our objective was the development of novel...
3.
Busignies V, Arruda D, Charrueau C, Ribeiro M, Lachages A, Malachias A, et al.
Mol Pharm
. 2020 Mar;
17(4):1159-1169.
PMID: 32125867
Currently, most nonviral nucleic acid vectors are in the form of colloidal suspensions administered primarily parenterally. This type of formulation and the mode of administration impose strong constraints such as...
4.
Hoffmann C, Djerir N, Danckaert A, Fernandes J, Roux P, Charrueau C, et al.
Sci Rep
. 2020 Mar;
10(1):3850.
PMID: 32123215
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to...
5.
Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nahse V, et al.
Nat Commun
. 2019 Dec;
10(1):5693.
PMID: 31836700
Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription...
6.
Pizzuto M, Bigey P, Lachages A, Hoffmann C, Ruysschaert J, Escriou V, et al.
J Control Release
. 2018 Aug;
287:67-77.
PMID: 30110615
Effective vaccine formulations consist of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response...
7.
Le Tallec B, Dutrillaux B, Lachages A, Millot G, Brison O, Debatisse M
Nat Struct Mol Biol
. 2011 Nov;
18(12):1421-3.
PMID: 22056772
Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type-dependent replication programs. Using a new approach, we...
8.
Letessier A, Millot G, Koundrioukoff S, Lachages A, Vogt N, Hansen R, et al.
Nature
. 2011 Jan;
470(7332):120-3.
PMID: 21258320
Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage...
9.
Gay S, Lachages A, Millot G, Courbet S, Letessier A, Debatisse M, et al.
EMBO Rep
. 2010 Jul;
11(9):698-704.
PMID: 20671737
In eukaryotes, only a fraction of replication origins fire at each S phase. Local histone acetylation was proposed to control firing efficiency of origins, but conflicting results were obtained. We...