Stephane Koundrioukoff
Overview
Explore the profile of Stephane Koundrioukoff including associated specialties, affiliations and a list of published articles.
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23
Citations
1047
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Recent Articles
1.
Hecht F, Valerio L, Goncalves C, Harinquet M, Ameziane El Hassani R, Carvalho D, et al.
Eur Thyroid J
. 2024 Jul;
13(4).
PMID: 39047147
Objective: Ionizing radiation generates genomic instability by promoting the accumulation of chromosomal rearrangements. The oncogenic translocation RET/PTC1 is present in more than 70% of radiation-induced thyroid cancers. Both RET and...
2.
Matos-Rodrigues G, Barroca V, Muhammad A, Dardillac E, Allouch A, Koundrioukoff S, et al.
EMBO J
. 2023 Sep;
42(20):e110844.
PMID: 37661798
Homologous recombination (HR) is a prominent DNA repair pathway maintaining genome integrity. Mutations in many HR genes lead to cancer predisposition. Paradoxically, the implication of the pivotal HR factor RAD51...
3.
Kim S, Maric C, Briu L, Fauchereau F, Baldacci G, Debatisse M, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445805
Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce...
4.
Brison O, Gnan S, Azar D, Koundrioukoff S, Melendez-Garcia R, Kim S, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(4):539-550.
PMID: 37024657
Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which delays mitotic onset. Under-replication of common fragile sites...
5.
Bauwens S, Lototska L, Koundrioukoff S, Debatisse M, Ye J, Gilson E, et al.
Life (Basel)
. 2021 Apr;
11(4).
PMID: 33804994
Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication through pericentromeric heterochromatin requires...
6.
Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nahse V, et al.
Nat Commun
. 2019 Dec;
10(1):5693.
PMID: 31836700
Common fragile sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Most CFSs nest in large expressed genes, suggesting that transcription...
7.
Mendez-Bermudez A, Lototska L, Bauwens S, Giraud-Panis M, Croce O, Jamet K, et al.
Mol Cell
. 2018 May;
70(3):449-461.e5.
PMID: 29727617
Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the event of replication stress, to chromosome fragility, aging, and cancer. Our knowledge of...
8.
Techer H, Koundrioukoff S, Nicolas A, Debatisse M
Nat Rev Genet
. 2017 Jul;
18(9):535-550.
PMID: 28714480
The interplay between replication stress and the S phase checkpoint is a key determinant of genome maintenance, and has a major impact on human diseases, notably, tumour initiation and progression....
9.
Hernandez-Perez S, Cabrera E, Amoedo H, Rodriguez-Acebes S, Koundrioukoff S, Debatisse M, et al.
Mol Oncol
. 2016 Jun;
10(8):1196-206.
PMID: 27296872
DNA replication control is a key process in maintaining genomic integrity. Monitoring DNA replication initiation is particularly important as it needs to be coordinated with other cellular events and should...
10.
Techer H, Koundrioukoff S, Carignon S, Wilhelm T, Millot G, Lopez B, et al.
Cell Rep
. 2016 Jan;
14(5):1114-1127.
PMID: 26804904
Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have remained unclear. We show that exogenous deoxyribonucleosides suppress both...