Michelle Debatis
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Explore the profile of Michelle Debatis including associated specialties, affiliations and a list of published articles.
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14
Citations
294
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Recent Articles
1.
Debatis M, Danz H, Tremblay J, Gaspie K, Kudej R, Vigdorovich V, et al.
PLoS One
. 2023 Nov;
18(11):e0291937.
PMID: 38011121
Single-domain antibodies (sdAbs) derived from Camelidae heavy-chain-only antibodies (also called nanobodies or VHHs) have advantages over conventional antibodies in terms of their small size and stability to pH and temperature...
2.
Mukherjee J, Ondeck C, Tremblay J, Archer J, Debatis M, Foss A, et al.
Sci Rep
. 2022 Jul;
12(1):11664.
PMID: 35803998
Single domain antibodies (sdAbs), also called nanobodies, have substantial biophysical advantages over conventional antibodies and are increasingly being employed as components of immunotherapeutic agents. One particularly favorable property is the...
3.
Markus J, Landry T, Stevens Z, Scott H, Llanos P, Debatis M, et al.
In Vitro Cell Dev Biol Anim
. 2020 Nov;
57(2):160-173.
PMID: 33237403
The gastrointestinal tract (GIT), in particular, the small intestine, plays a significant role in food digestion, fluid and electrolyte transport, drug absorption and metabolism, and nutrient uptake. As the longest...
4.
Krautz-Peterson G, Debatis M, Tremblay J, Oliveira S, Dadara A, Skelly P, et al.
PLoS Negl Trop Dis
. 2017 Jan;
11(1):e0005306.
PMID: 28095417
Schistosomiasis is a major disease of the developing world for which no vaccine has been successfully commercialized. While numerous Schistosoma mansoni worm antigens have been identified that elicit antibody responses...
5.
Moayeri M, Tremblay J, Debatis M, Dmitriev I, Kashentseva E, Yeh A, et al.
Clin Vaccine Immunol
. 2016 Jan;
23(3):213-8.
PMID: 26740390
Bacillus anthracis, the causative agent of anthrax, secretes three polypeptides, which form the bipartite lethal and edema toxins (LT and ET, respectively). The common component in these toxins, protective antigen...
6.
Sheoran A, Dmitriev I, Kashentseva E, Cohen O, Mukherjee J, Debatis M, et al.
Infect Immun
. 2014 Nov;
83(1):286-91.
PMID: 25368111
Hemolytic-uremic syndrome (HUS), caused by Shiga toxin (Stx)-producing Escherichia coli (STEC), remains untreatable. Production of human monoclonal antibodies against Stx, which are highly effective in preventing Stx sequelae in animal...
7.
Barrera D, Rosenberg J, Chiu J, Chang Y, Debatis M, Ngoi S, et al.
Plant Biotechnol J
. 2014 Sep;
13(1):117-24.
PMID: 25229405
We have produced three antitoxins consisting of the variable domains of camelid heavy chain-only antibodies (VH H) by expressing the genes in the chloroplast of green algae. These antitoxins accumulate...
8.
Mukherjee J, Dmitriev I, Debatis M, Tremblay J, Beamer G, Kashentseva E, et al.
PLoS One
. 2014 Aug;
9(8):e106422.
PMID: 25170904
Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents (VNAs) consisting of two or more linked, toxin-neutralizing...
9.
Tremblay J, Mukherjee J, Leysath C, Debatis M, Ofori K, Baldwin K, et al.
Infect Immun
. 2013 Oct;
81(12):4592-603.
PMID: 24082082
Shiga toxin-producing Escherichia coli (STEC) is a major cause of severe food-borne disease worldwide, and two Shiga toxins, Stx1 and Stx2, are primarily responsible for the serious disease consequence, hemolytic-uremic...
10.
Nundel K, Busto P, Debatis M, Marshak-Rothstein A
J Leukoc Biol
. 2013 Jun;
94(5):865-75.
PMID: 23804807
The protein kinase Btk has been implicated in the development, differentiation, and activation of B cells through its role in the BCR and TLR signaling cascades. These receptors and in...