Jacqueline M Tremblay
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Explore the profile of Jacqueline M Tremblay including associated specialties, affiliations and a list of published articles.
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33
Citations
632
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Recent Articles
1.
Rice-Boucher P, Kashentseva E, Dmitriev I, Guo H, Tremblay J, Shoemaker C, et al.
bioRxiv
. 2025 Feb;
PMID: 39974927
Safe and efficient nucleic acid delivery to targeted cell populations remains a significant unmet need in the fields of cell and gene therapy. Towards this end, we pursued Adenoviral vectors...
2.
Yang Y, Vedvyas Y, Alcaina Y, Trumper S, Babu D, Min I, et al.
JCI Insight
. 2024 Nov;
9(22).
PMID: 39576012
The application of chimeric antigen receptor (CAR) T cell therapy in solid tumors is hindered by life-threatening toxicities resulting from on-target, off-tumor killing of nonmalignant cells that express low levels...
3.
Debatis M, Danz H, Tremblay J, Gaspie K, Kudej R, Vigdorovich V, et al.
PLoS One
. 2023 Nov;
18(11):e0291937.
PMID: 38011121
Single-domain antibodies (sdAbs) derived from Camelidae heavy-chain-only antibodies (also called nanobodies or VHHs) have advantages over conventional antibodies in terms of their small size and stability to pH and temperature...
4.
Liu Z, Lee P, Krez N, Lam K, Liu H, Przykopanski A, et al.
Nat Commun
. 2023 Apr;
14(1):2338.
PMID: 37095076
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain...
5.
Lynch J, Gonzalez-Prieto C, Reeves A, Bae S, Powale U, Godbole N, et al.
Cell Host Microbe
. 2023 Apr;
31(4):634-649.e8.
PMID: 37003258
Drug platforms that enable the directed delivery of therapeutics to sites of diseases to maximize efficacy and limit off-target effects are needed. Here, we report the development of PROTEcT, a...
6.
Gelfat I, Aqeel Y, Tremblay J, Jaskiewicz J, Shrestha A, Lee J, et al.
PLoS Pathog
. 2022 Sep;
18(9):e1010713.
PMID: 36107831
Enteric microbial pathogens, including Escherichia coli, Shigella and Cryptosporidium species, take a particularly heavy toll in low-income countries and are highly associated with infant mortality. We describe here a means...
7.
Mukherjee J, Ondeck C, Tremblay J, Archer J, Debatis M, Foss A, et al.
Sci Rep
. 2022 Jul;
12(1):11664.
PMID: 35803998
Single domain antibodies (sdAbs), also called nanobodies, have substantial biophysical advantages over conventional antibodies and are increasingly being employed as components of immunotherapeutic agents. One particularly favorable property is the...
8.
Lam K, Tremblay J, Perry K, Ichtchenko K, Shoemaker C, Jin R
PLoS Pathog
. 2022 Jan;
18(1):e1010169.
PMID: 34990480
Botulinum neurotoxins (BoNTs) are among the deadliest of bacterial toxins. BoNT serotype A and B in particular pose the most serious threat to humans because of their high potency and...
9.
Dulal H, Vance D, Neupane D, Chen X, Tremblay J, Shoemaker C, et al.
Infect Immun
. 2021 Dec;
90(2):e0051521.
PMID: 34898253
Typhoid toxin is secreted by the typhoid fever-causing bacterial pathogen Salmonella enterica serovar Typhi and has tropism for immune cells and brain endothelial cells. Here, we generated a camelid single-domain...
10.
Lee M, Lu Z, Shoemaker C, Tremblay J, St Croix B, Seaman S, et al.
J Control Release
. 2021 Apr;
334:106-113.
PMID: 33872627
For the developing field of gene therapy the successful address of the basic requirement effective gene delivery has remained a critical barrier. In this regard, the "Holy Grail" vector envisioned...