Michele S Dowless
Overview
Explore the profile of Michele S Dowless including associated specialties, affiliations and a list of published articles.
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8
Citations
456
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Recent Articles
1.
Bhagwat S, Mur C, Vandekopple M, Zhao B, Shen W, Marugan C, et al.
Cancer Res
. 2024 Dec;
85(4):777-790.
PMID: 39652577
Targeting of the estrogen receptor (ER) by antiestrogens is the standard of care for patients with ER+ HER2- advanced/metastatic breast cancer. Although antiestrogens that degrade ERα (fulvestrant) or block estrogen...
2.
Du J, Yan L, Torres R, Gong X, Bian H, Marugan C, et al.
Mol Cancer Ther
. 2019 Sep;
18(12):2207-2219.
PMID: 31530649
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle...
3.
Konicek B, Stephens J, McNulty A, Robichaud N, Peery R, Dumstorf C, et al.
Cancer Res
. 2011 Jan;
71(5):1849-57.
PMID: 21233335
Activation of the translation initiation factor 4E (eIF4E) promotes malignant transformation and metastasis. Signaling through the AKT-mTOR pathway activates eIF4E by phosphorylating the inhibitory 4E binding proteins (4E-BP). This liberates...
4.
Graff J, Konicek B, Lynch R, Dumstorf C, Dowless M, McNulty A, et al.
Cancer Res
. 2009 Apr;
69(9):3866-73.
PMID: 19383915
Elevated eukaryotic translation initiation factor 4E (eIF4E) function induces malignancy in experimental models by selectively enhancing translation of key malignancy-related mRNAs (c-myc and BCL-2). eIF4E activation may reflect increased eIF4E...
5.
Graff J, Konicek B, Vincent T, Lynch R, Monteith D, Weir S, et al.
J Clin Invest
. 2007 Sep;
117(9):2638-48.
PMID: 17786246
Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors...
6.
Schmidt R, Ficorilli J, Zhang Y, Bramlett K, Beyer T, Borchert K, et al.
J Lipid Res
. 2006 Jan;
47(5):1037-44.
PMID: 16415294
Hypercholesterolemia is a major risk factor for coronary artery disease. Oxysterols are known to inhibit cholesterol biosynthesis and have been explored as potential antihypercholesterolemic agents. The ability of 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one (15-ketosterol)...
7.
Dowless M, Barbee J, Borchert K, Bocchinfuso W, Houck K
Eur J Pharmacol
. 2005 Apr;
512(1):9-13.
PMID: 15814084
Forskolin and cAMP have been shown to have paradoxical effects in the regulation of expression levels of mRNA of cytochrome P450 3A (CYP3A) family members. We demonstrate in this study...
8.
Bramlett K, Houck K, Borchert K, Dowless M, Kulanthaivel P, Zhang Y, et al.
J Pharmacol Exp Ther
. 2003 Aug;
307(1):291-6.
PMID: 12893846
Natural products have been identified as ligands for a number of members of the nuclear hormone receptor (NHR) superfamily. Often these natural products are used as dietary supplements to treat...