Michele L LeNoue-Newton
Overview
Explore the profile of Michele L LeNoue-Newton including associated specialties, affiliations and a list of published articles.
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12
Citations
277
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Recent Articles
1.
Radiomics and Deep Learning Prediction of Immunotherapy-Induced Pneumonitis From Computed Tomography
Smith D, Lippenszky L, LeNoue-Newton M, Jain N, Mittendorf K, Micheel C, et al.
JCO Clin Cancer Inform
. 2025 Feb;
9:e2400198.
PMID: 39977708
Purpose: Primary barriers to application of immune checkpoint inhibitor (ICI) therapy for cancer include severe side effects (such as potentially life threatening pneumonitis [PN]), which can cause the discontinuation of...
2.
Lippenszky L, Mittendorf K, Kiss Z, LeNoue-Newton M, Napan-Molina P, Rahman P, et al.
JCO Clin Cancer Inform
. 2024 Mar;
8:e2300207.
PMID: 38427922
Purpose: Although immune checkpoint inhibitors (ICIs) have improved outcomes in certain patients with cancer, they can also cause life-threatening immunotoxicities. Predicting immunotoxicity risks alongside response could provide a personalized risk-benefit...
3.
Sanz-Garcia E, Brown S, Lavery J, Weiss J, Fuchs H, Newcomb A, et al.
Cancer Res Commun
. 2024 Feb;
4(2):475-486.
PMID: 38329392
Significance: Utilizing the GENIE BPC registry, this study found that PM in patients with colorectal cancer occur more frequently in females and right-sided primary tumors and are associated with worse...
4.
de Bruijn I, Kundra R, Mastrogiacomo B, Tran T, Sikina L, Mazor T, et al.
Cancer Res
. 2023 Sep;
83(23):3861-3867.
PMID: 37668528
Significance: Enhanced cBioPortal features allow clinicians and researchers to effectively investigate longitudinal clinico-genomic data from patients with cancer, which will improve exploration of data from the AACR Project GENIE Biopharma...
5.
Scharpf R, Balan A, Ricciuti B, Fiksel J, Cherry C, Wang C, et al.
Cancer Res
. 2022 Sep;
82(21):4058-4078.
PMID: 36074020
Significance: The complex genomic landscape of RAS-mutant tumors is reflective of selection processes in a cancer lineage-specific and context-dependent manner, highlighting differential therapeutic vulnerabilities that can be clinically translated.
6.
Brown B, Zhang Y, Kim S, Finneran P, Yan Y, Du Z, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2206588119.
PMID: 35867821
Oncogenic mutations within the epidermal growth factor receptor (EGFR) are found in 15 to 30% of all non-small-cell lung carcinomas. The term exon 19 deletion (ex19del) is collectively used to...
7.
Pugh T, Bell J, Bruce J, Doherty G, Galvin M, Green M, et al.
Cancer Discov
. 2022 Jul;
12(9):2044-2057.
PMID: 35819403
Significance: AACR Project GENIE has now accrued data from >110,000 tumors, placing it among the largest repository of publicly available, clinically annotated genomic data in the world. GENIE has emerged...
8.
LeNoue-Newton M, Chen S, Stricker T, Hyman D, Blauvelt N, Bedard P, et al.
Clin Cancer Res
. 2022 Feb;
28(10):2118-2130.
PMID: 35190802
Purpose: We wanted to determine the prognosis and the phenotypic characteristics of hormone receptor-positive advanced breast cancer tumors harboring an ERBB2 mutation in the absence of a HER2 amplification. Experimental...
9.
Kehl K, Riely G, Lepisto E, Lavery J, Warner J, LeNoue-Newton M, et al.
JAMA Netw Open
. 2021 Jul;
4(7):e2117547.
PMID: 34309669
Importance: Contemporary observational cancer research requires associating genomic biomarkers with reproducible end points; overall survival (OS) is a key end point, but interpretation can be challenging when multiple lines of...
10.
Thomas S, Lichtenberg T, Dang K, Fitzsimons M, Grossman R, Kundra R, et al.
JCO Clin Cancer Inform
. 2020 Aug;
4:691-699.
PMID: 32755461
Purpose: As data-sharing projects become increasingly frequent, so does the need to map data elements between multiple classification systems. A generic, robust, shareable architecture will result in increased efficiency and...