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Nikolaus Schultz

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Articles 279
Citations 52864
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Recent Articles
1.
Zammarrelli 3rd W, Nandakumar S, Kertowidjojo E, Nguyen B, Moukarzel L, Da Cruz Paula A, et al.
Gynecol Oncol . 2025 Mar; 195:89-97. PMID: 40081112
Objective: The molecular underpinnings of primary treatment-naïve endometrial carcinoma (EC) are well described. Here we sought to characterize the genomic landscape of distant metastatic EC. Methods: Distant metastatic ECs from...
2.
Mahmoud A, Choi P, Sukhwa C, Pintar J, Walch H, Zhao N, et al.
bioRxiv . 2025 Mar; PMID: 40027618
Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), a gastrointestinal...
3.
Boehm K, El Nahhas O, Marra A, Waters M, Jee J, Braunstein L, et al.
Nat Commun . 2025 Mar; 16(1):2106. PMID: 40025017
The Oncotype DX® Recurrence Score (RS) is an assay for hormone receptor-positive early breast cancer with extensively validated predictive and prognostic value. However, its cost and lag time have limited...
4.
Aprati T, Day C, Lee D, Pan A, Jee J, Tarantino G, et al.
bioRxiv . 2025 Feb; PMID: 39975034
Metastasis drives mortality and morbidity in cancer. While some patients develop broad metastatic disease across multiple organs, others exhibit organ-specific spread. To identify mechanisms underlying metastatic organotropism, we analyzed clinico-genomic...
5.
Gaeta B, Eichholz J, Walch H, Ilica A, Ilica A, Boe L, et al.
Int J Radiat Oncol Biol Phys . 2025 Feb; PMID: 39929348
Purpose: Precision medicine according to molecularly defined subgroups offers great potential to improve outcomes for patients with metastatic lung adenocarcinoma. This study describes clinical outcomes and the impact of co-occurring...
6.
Arora K, Suehnholz S, Zhang H, Ostrovnaya I, Kundra R, Nandakumar S, et al.
JAMA Oncol . 2025 Jan; PMID: 39786754
Importance: Although differences in the prevalence of key cancer-specific somatic mutations as a function of genetic ancestry among patients with cancer has been well-established, few studies have addressed the practical...
7.
Varghese A, Perry M, Chou J, Nandakumar S, Muldoon D, Erakky A, et al.
Nat Med . 2025 Jan; 31(2):466-477. PMID: 39753968
Nearly all pancreatic adenocarcinomas (PDAC) are genomically characterized by KRAS exon 2 mutations. Most patients with PDAC present with advanced disease and are treated with cytotoxic therapy. Genomic biomarkers prognostic...
8.
Kader T, Lin J, Hug C, Coy S, Chen Y, de Bruijn I, et al.
Cancer Discov . 2024 Dec; PMID: 39704522
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this,...
9.
Zucker M, Perry M, Gould S, Elkrief A, Safonov A, Thummalapalli R, et al.
Cell . 2024 Dec; 188(3):851-867.e17. PMID: 39701102
The canonical model of tumor suppressor gene (TSG)-mediated oncogenesis posits that loss of both alleles is necessary for inactivation. Here, through allele-specific analysis of sequencing data from 48,179 cancer patients,...
10.
Foote M, White J, Chatila W, Argiles G, Lu S, Rousseau B, et al.
Clin Cancer Res . 2024 Nov; 31(2):376-386. PMID: 39561276
Purpose: Mutational data from multiple solid and liquid biospecimens of a single patient are often integrated to track cancer evolution. However, there is no accepted framework to resolve if individual...