Michela Silacci
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Explore the profile of Michela Silacci including associated specialties, affiliations and a list of published articles.
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11
Citations
310
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Recent Articles
1.
Lyman M, Lieuw V, Richardson R, Timmer A, Stewart C, Granger S, et al.
J Biol Chem
. 2018 Apr;
293(24):9326-9334.
PMID: 29678878
Despite the success of current biological therapeutics for rheumatoid arthritis, these therapies, targeting individual cytokines or pathways, produce beneficial responses in only about half of patients. Therefore, better therapeutics are...
2.
Silacci M, Lembke W, Woods R, Attinger-Toller I, Baenziger-Tobler N, Batey S, et al.
MAbs
. 2015 Sep;
8(1):141-9.
PMID: 26390837
Biologic treatment options such as tumor necrosis factor (TNF) inhibitors have revolutionized the treatment of inflammatory diseases, including rheumatoid arthritis. Recent data suggest, however, that full and long-lasting responses to...
3.
Silacci M, Baenziger-Tobler N, Lembke W, Zha W, Batey S, Bertschinger J, et al.
J Biol Chem
. 2014 Apr;
289(20):14392-8.
PMID: 24692552
Fynomers are small binding proteins derived from the human Fyn SH3 domain. Using phage display technology, Fynomers were generated inhibiting the activity of the proinflammatory cytokine interleukin-17A (IL-17A). One specific...
4.
von Lukowicz T, Silacci M, Wyss M, Trachsel E, Lohmann C, Buck A, et al.
J Nucl Med
. 2007 Apr;
48(4):582-7.
PMID: 17401095
Unlabelled: Targeting proteins that are overexpressed in atherosclerotic plaques may open novel diagnostic applications. The C domain of tenascin-C is absent from normal adult tissues but can be inserted during...
5.
Trachsel E, Bootz F, Silacci M, Kaspar M, Kosmehl H, Neri D
Arthritis Res Ther
. 2007 Jan;
9(1):R9.
PMID: 17261171
The antibody-mediated targeted delivery of cytokines to sites of disease is a promising avenue for cancer therapy, but it is largely unexplored for the treatment of chronic inflammatory conditions. Using...
6.
Silacci M, Brack S, Spath N, Buck A, Hillinger S, Arni S, et al.
Protein Eng Des Sel
. 2006 Aug;
19(10):471-8.
PMID: 16928692
We had previously reported that splice isoforms of tenascin-C containing the extra-domain C are virtually absent in normal adult tissues but are highly abundant in high-grade astrocytomas, with a prominent...
7.
Ettorre A, Rosli C, Silacci M, Brack S, McCombie G, Knochenmuss R, et al.
Proteomics
. 2006 Jul;
6(16):4496-505.
PMID: 16858729
The identification of biomarkers from serum or plasma is often hindered by a few proteins present at high concentrations, which may obscure less abundant proteins. Ideal serum depletion strategies would...
8.
Berndt A, Anger K, Richter P, Borsi L, Brack S, Silacci M, et al.
J Cancer Res Clin Oncol
. 2006 Jun;
132(8):537-46.
PMID: 16788848
Purpose: Through alternative splicing of the extracellular matrix protein tenascin-C (Tn-C) primary transcript nine type III homology repeats can be independently included or omitted. Large, low spliced Tn-C variants (Tn-C(L))...
9.
Brack S, Silacci M, Birchler M, Neri D
Clin Cancer Res
. 2006 May;
12(10):3200-8.
PMID: 16707621
Background: The targeted delivery of bioactive molecules with antibodies specific to tumor-associated antigens represents a promising strategy for improving the efficacy of tumor therapy. The large isoform of tenascin-C, an...
10.
Design, construction, and characterization of a large synthetic human antibody phage display library
Silacci M, Brack S, Schirru G, Marlind J, Ettorre A, Merlo A, et al.
Proteomics
. 2005 May;
5(9):2340-50.
PMID: 15880779
Advances in proteomic research allow the identification of several hundred protein components in complex biological specimens. Structural information is typically lost during proteomic investigations. For this reason, the rapid isolation...