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Michela Perego

Explore the profile of Michela Perego including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 1920
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Recent Articles
1.
Ugolini A, De Leo A, Yu X, Scirocchi F, Liu X, Peixoto B, et al.
Cancer Discov . 2025 Feb; PMID: 40014923
Despite functional heterogeneity, high frequency of intratumoral neutrophils predicts poor clinical outcomes. The tumor microenvironment reprograms neutrophils into immunosuppressive subsets that hinder anti-cancer immunity, thereby contributing to tumor growth and...
2.
Perego M, Yeon M, Agarwal E, Milcarek A, Bertolini I, Camisaschi C, et al.
J Clin Invest . 2025 Jan; 135(2). PMID: 39817447
No abstract available.
3.
Perego M, Yeon M, Agarwal E, Milcarek A, Bertolini I, Camisaschi C, et al.
J Clin Invest . 2024 Aug; 134(22. PMID: 39213189
The activation of innate immunity and associated interferon (IFN) signaling have been implicated in cancer, but the regulators are elusive and links to tumor suppression remain undetermined. Here, we found...
4.
Monti M, Benerini Gatta L, Bugatti M, Pezzali I, Picinoli S, Manfredi M, et al.
J Transl Med . 2024 Jan; 22(1):35. PMID: 38191367
Background: Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular...
5.
Bertolini I, Perego M, Ghosh J, Kossenkov A, Altieri D
Oncogene . 2023 Jun; 42(27):2195. PMID: 37328686
No abstract available.
6.
Bertolini I, Perego M, Nefedova Y, Lin C, Milcarek A, Vogel P, et al.
J Clin Invest . 2023 Mar; 133(8). PMID: 36892943
The origin of breast cancer, whether primary or recurrent, is unknown. Here, we show that invasive breast cancer cells exposed to hypoxia release small extracellular vesicles (sEVs) that disrupt the...
7.
Bertolini I, Perego M, Ghosh J, Kossenkov A, Altieri D
Oncogene . 2023 Jan; 42(9):708. PMID: 36707623
No abstract available.
8.
Fu S, Deng H, Bertolini I, Perego M, Chen E, Sanseviero E, et al.
Cancer Immunol Res . 2022 Dec; 11(3):278-289. PMID: 36548516
Pathologically activated neutrophils (PMN) with immunosuppressive activity, which are termed myeloid-derived suppressor cells (PMN-MDSC), play a critical role in regulating tumor progression. These cells have been implicated in promoting tumor...
9.
Kossenkov A, Milcarek A, Notta F, Jang G, Wilson J, Gallinger S, et al.
PLoS One . 2022 Oct; 17(10):e0273520. PMID: 36223343
Changes in metabolism are a hallmark of cancer, but molecular signatures of altered bioenergetics to aid in clinical decision-making do not currently exist. We recently identified a group of human...
10.
Perego M, Fu S, Cao Y, Kossenkov A, Yao M, Bonner E, et al.
J Leukoc Biol . 2022 Jun; 112(5):955-968. PMID: 35726818
Transitory appearance of immune suppressive polymorphonuclear neutrophils (PMNs) defined as myeloid-derived suppressor cells (PMNs-MDSCs) in newborns is important for their protection from inflammation associated with newly established gut microbiota. Here,...