Michal K Stachowiak
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Explore the profile of Michal K Stachowiak including associated specialties, affiliations and a list of published articles.
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47
Citations
847
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Recent Articles
1.
Dhiman S, Manoj N, Liput M, Sangwan A, Diehl J, Balcerak A, et al.
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38891836
As human progenitor cells differentiate into neurons, the activities of many genes change; these changes are maintained within a narrow range, referred to as genome homeostasis. This process, which alters...
2.
Dual-Hit Strategy for Therapeutic Targeting of Pancreatic Cancer in Patient-Derived Xenograft Tumors
Roy Chaudhuri T, Lin Q, Stachowiak E, Rosario S, Spernyak J, Ma W, et al.
Clin Cancer Res
. 2024 Jan;
30(7):1367-1381.
PMID: 38270582
Purpose: Paracrine activation of pro-fibrotic hedgehog (HH) signaling in pancreatic ductal adenocarcinoma (PDAC) results in stromal amplification that compromises tumor drug delivery, efficacy, and patient survival. Interdiction of HH-mediated tumor-stroma...
3.
Dutta A, Biber J, Bae Y, Augustyniak J, Liput M, Stachowiak E, et al.
Annu Int Conf IEEE Eng Med Biol Soc
. 2022 Sep;
2022:1585-1589.
PMID: 36085803
The physiological origin of the aperiodic signal present in the electrophysiological recordings, called l/f neural noise, is unknown; nevertheless, it has been associated with health and disease. The power spectrum...
4.
Decker B, Liput M, Abdellatif H, Yergeau D, Bae Y, Jornet J, et al.
Int J Mol Sci
. 2021 Jan;
22(1).
PMID: 33396256
During the development of mouse embryonic stem cells (ESC) to neuronal committed cells (NCC), coordinated changes in the expression of 2851 genes take place, mediated by the nuclear form of...
5.
Dutta A, Karanth S, Bhattacharya M, Liput M, Augustyniak J, Cheung M, et al.
Sci Rep
. 2020 Dec;
10(1):20987.
PMID: 33268815
Homeostatic control of neuronal excitability by modulation of synaptic inhibition (I) and excitation (E) of the principal neurons is important during brain maturation. The fundamental features of in-utero brain development,...
6.
Benson C, Powell H, Liput M, Dinham S, Freedman D, Ignatowski T, et al.
Front Cell Neurosci
. 2020 Oct;
14:233.
PMID: 33005129
Schizophrenia (SZ) is a neurodevelopmental genetic disorder in which maternal immune activation (MIA) and increased tumor necrosis factor-α (TNF-α) may contribute. Previous studies using iPSC-derived cerebral organoids and neuronal cells...
7.
Klejbor I, Mahmood S, Melka N, Ebertowska A, Morys J, Stachowiak E, et al.
Acta Neurobiol Exp (Wars)
. 2020 Sep;
80(3):305-321.
PMID: 32990288
In humans, pyruvate dehydrogenase complex (PDC) deficiency impairs brain energy metabolism by reducing the availability of the functional acetyl‑CoA pool. This "hypometabolic defect" results in congenital lactic acidosis and abnormalities...
8.
Dutta A, Das A, Kondziella D, Stachowiak M
Brain Sci
. 2020 May;
10(5).
PMID: 32370257
Coronavirus disease (COVID-19) has been declared as a pandemic by the World Health Organization (WHO).[...].
9.
Wirdatmadja S, Johari P, Desai A, Bae Y, Stachowiak E, Stachowiak M, et al.
IEEE Trans Neural Syst Rehabil Eng
. 2019 Jan;
27(2):108-117.
PMID: 30624220
Miniaturization of implantable devices is an important challenge for future brain-computer interface applications, and in particular for achieving precise neuron stimulation. For stimulation that utilizes light, i.e., optogenetics, the light...
10.
Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophrenia
Narla S, Decker B, Sarder P, Stachowiak E, Stachowiak M
Results Probl Cell Differ
. 2018 Sep;
66:137-162.
PMID: 30209658
Schizophrenia is a neurodevelopmental disorder characterized by complex aberrations in the structure, wiring, and chemistry of multiple neuronal systems. The abnormal developmental trajectory of the brain is established during gestation,...