Michal Gucwa
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Explore the profile of Michal Gucwa including associated specialties, affiliations and a list of published articles.
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10
Citations
45
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Recent Articles
1.
Rubach P, Majorek K, Gucwa M, Murzyn K, Wlodawer A, Minor W
Expert Opin Drug Discov
. 2025 Jan;
20(2):163-176.
PMID: 39789967
Introduction: Macromolecular X-ray crystallography (XRC), nuclear magnetic resonance (NMR), and cryo-electron microscopy (cryoEM) are the primary techniques for determining atomic-level, three-dimensional structures of macromolecules essential for drug discovery. With advancements...
2.
Majorek K, Gucwa M, Murzyn K, Minor W
Front Chem
. 2024 Sep;
12:1426211.
PMID: 39246722
Understanding the functions of metal ions in biological systems is crucial for many aspects of research, including deciphering their roles in diseases and potential therapeutic use. Structural information about the...
3.
Gucwa M, Bijak V, Zheng H, Murzyn K, Minor W
IUCrJ
. 2024 Aug;
11(Pt 5):871-877.
PMID: 39141478
Identifying and characterizing metal-binding sites (MBS) within macromolecular structures is imperative for elucidating their biological functions. CheckMyMetal (CMM) is a web based tool that facilitates the interactive validation of MBS...
4.
Wu D, Hierons S, Polepalli S, Gucwa M, Fritzen R, Markiewicz M, et al.
J Lipid Res
. 2024 May;
65(6):100560.
PMID: 38750995
Zinc is required for virtually all biological processes. In plasma, Zn is predominantly transported by human serum albumin (HSA), which possesses two Zn-binding sites of differing affinities (sites A and...
5.
Zheng H, Zhang H, Zhong J, Gucwa M, Zhang Y, Ma H, et al.
Res Sq
. 2024 Mar;
PMID: 38463967
Metal ions are vital components in many proteins for the inference and engineering of protein function, with coordination complexity linked to structural (4-residue predominate), catalytic (3-residue predominate), or regulatory (2-residue...
6.
Bijak V, Szczygiel M, Lenkiewicz J, Gucwa M, Cooper D, Murzyn K, et al.
Expert Opin Drug Discov
. 2023 Aug;
18(11):1221-1230.
PMID: 37592849
Introduction: Macromolecular X-ray crystallography and cryo-EM are currently the primary techniques used to determine the three-dimensional structures of proteins, nucleic acids, and viruses. Structural information has been critical to drug...
7.
Bijak V, Gucwa M, Lenkiewicz J, Murzyn K, Cooper D, Minor W
Nihon Kesshō Gakkaishi
. 2023 Jul;
65(1):10-16.
PMID: 37416056
The overall quality of the experimentally determined structures contained in the PDB is exceptionally high, mainly due to the continuous improvement of model building and structural validation programs. Improving reproducibility...
8.
Lenkiewicz J, Bijak V, Poonuganti S, Szczygiel M, Gucwa M, Murzyn K, et al.
Struct Dyn
. 2023 Jun;
10(3):034701.
PMID: 37350851
Over the course of the pandemic caused by SARS-CoV-2, structural biologists have worked hand in hand with groups developing vaccines and treatments. However, relying solely on and clinical studies may...
9.
Wu D, Gucwa M, Czub M, Cooper D, Shabalin I, Fritzen R, et al.
Chem Sci
. 2023 Jun;
14(23):6244-6258.
PMID: 37325156
Serum albumin-Co interactions are of clinical importance. They play a role in mediating the physiological effects associated with cobalt toxicity and are central to the albumin cobalt binding (ACB) assay...
10.
Gucwa M, Lenkiewicz J, Zheng H, Cymborowski M, Cooper D, Murzyn K, et al.
Protein Sci
. 2022 Dec;
32(1):e4525.
PMID: 36464767
Metal ions bound to macromolecules play an integral role in many cellular processes. They can directly participate in catalytic mechanisms or be essential for the structural integrity of proteins and...