David R Cooper
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Explore the profile of David R Cooper including associated specialties, affiliations and a list of published articles.
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44
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1229
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Recent Articles
1.
Murali M, Saquing J, Lu S, Gao Z, Watts E, Jordan B, et al.
Genome Res
. 2025 Mar;
PMID: 40086882
Long-read RNA-seq has shed light on transcriptomic complexity, but questions remain about the functionality of downstream protein products. We introduce Biosurfer, a computational approach for comparing protein isoforms, while systematically...
2.
Murali M, Saquing J, Lu S, Gao Z, Jordan B, Wakefield Z, et al.
bioRxiv
. 2024 Apr;
PMID: 38559226
Long-read RNA sequencing has shed light on transcriptomic complexity, but questions remain about the functionality of downstream protein products. We introduce Biosurfer, a computational approach for comparing protein isoforms, while...
3.
Bijak V, Szczygiel M, Lenkiewicz J, Gucwa M, Cooper D, Murzyn K, et al.
Expert Opin Drug Discov
. 2023 Aug;
18(11):1221-1230.
PMID: 37592849
Introduction: Macromolecular X-ray crystallography and cryo-EM are currently the primary techniques used to determine the three-dimensional structures of proteins, nucleic acids, and viruses. Structural information has been critical to drug...
4.
Bijak V, Gucwa M, Lenkiewicz J, Murzyn K, Cooper D, Minor W
Nihon Kesshō Gakkaishi
. 2023 Jul;
65(1):10-16.
PMID: 37416056
The overall quality of the experimentally determined structures contained in the PDB is exceptionally high, mainly due to the continuous improvement of model building and structural validation programs. Improving reproducibility...
5.
Wu D, Gucwa M, Czub M, Cooper D, Shabalin I, Fritzen R, et al.
Chem Sci
. 2023 Jun;
14(23):6244-6258.
PMID: 37325156
Serum albumin-Co interactions are of clinical importance. They play a role in mediating the physiological effects associated with cobalt toxicity and are central to the albumin cobalt binding (ACB) assay...
6.
Gucwa M, Lenkiewicz J, Zheng H, Cymborowski M, Cooper D, Murzyn K, et al.
Protein Sci
. 2022 Dec;
32(1):e4525.
PMID: 36464767
Metal ions bound to macromolecules play an integral role in many cellular processes. They can directly participate in catalytic mechanisms or be essential for the structural integrity of proteins and...
7.
Minor W, Cymborowski M, Borek D, Cooper D, Chruszcz M, Otwinowski Z
Protein Sci
. 2021 Nov;
31(1):259-268.
PMID: 34783106
Herein we present the newest version of the HKL-3000 system that integrates data collection, data reduction, phasing, model building, refinement, and validation. The system significantly accelerates the process of structure...
8.
Zhang H, Chen P, Ma H, Woinska M, Liu D, Cooper D, et al.
IUCrJ
. 2021 Oct;
8(Pt 6).
PMID: 34614039
Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED ( etal binding sites, pitopes and...
9.
Grabowski M, Macnar J, Cymborowski M, Cooper D, Shabalin I, Gilski M, et al.
IUCrJ
. 2021 May;
8(Pt 3):395-407.
PMID: 33953926
As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have...
10.
Grabowski M, Cooper D, Brzezinski D, Macnar J, Shabalin I, Cymborowski M, et al.
Nucl Instrum Methods Phys Res B
. 2021 Feb;
489:30-40.
PMID: 33603257
Intense X-rays available at powerful synchrotron beamlines provide macromolecular crystallographers with an incomparable tool for investigating biological phenomena on an atomic scale. The resulting insights into the mechanism's underlying biological...