Michael W Roe
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Explore the profile of Michael W Roe including associated specialties, affiliations and a list of published articles.
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38
Citations
1456
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Recent Articles
1.
Schulman J, Szczesniak L, Bunker E, Nelson H, Roe M, Wagner 2nd L, et al.
Cell Death Differ
. 2019 Apr;
26(12):2682-2694.
PMID: 30976095
Bok (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, but the cellular role that Bok plays is controversial. Remarkably, endogenous Bok...
2.
Kono T, Tong X, Taleb S, Bone R, Iida H, Lee C, et al.
Diabetes
. 2018 Aug;
67(11):2293-2304.
PMID: 30131394
Store-operated Ca entry (SOCE) is a dynamic process that leads to refilling of endoplasmic reticulum (ER) Ca stores through reversible gating of plasma membrane Ca channels by the ER Ca...
3.
Nelson H, Leech C, Kopp R, Roe M
Int J Mol Sci
. 2018 May;
19(5).
PMID: 29783744
Store-operated calcium entry (SOCE), a fundamentally important homeostatic and Ca signaling pathway in many types of cells, is activated by the direct interaction of stromal interaction molecule 1 (STIM1), an...
4.
Nelson H, Roe M
Exp Biol Med (Maywood)
. 2018 Jan;
243(5):451-472.
PMID: 29363328
Ca release from the endoplasmic reticulum is an important component of Ca signal transduction that controls numerous physiological processes in eukaryotic cells. Release of Ca from the endoplasmic reticulum is...
5.
Leech C, Kopp R, Nelson H, Nandi J, Roe M
J Biol Chem
. 2016 Dec;
292(6):2266-2277.
PMID: 28003364
Stromal interaction molecule 1 (STIM1) regulates store-operated Ca entry (SOCE) and other ion channels either as an endoplasmic reticulum Ca-sensing protein or when present in the plasma membrane. However, the...
6.
Takatani T, Shirakawa J, Roe M, Leech C, Maier B, Mirmira R, et al.
Sci Rep
. 2016 Oct;
6:34969.
PMID: 27721427
No abstract available.
7.
Takatani T, Shirakawa J, Roe M, Leech C, Maier B, Mirmira R, et al.
Sci Rep
. 2016 Jul;
6:28177.
PMID: 27378176
Endoplasmic reticulum (ER) stress is among several pathological features that underlie β-cell failure in the development of type 1 and type 2 diabetes. Adaptor proteins in the insulin/insulin-like-growth factor-1 signaling...
8.
Chepurny O, Holz G, Roe M, Leech C
Mol Endocrinol
. 2016 Apr;
30(6):614-29.
PMID: 27082897
GPR119 is a G protein-coupled receptor expressed on intestinal L cells that synthesize and secrete the blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1). GPR119 agonists stimulate the release of GLP-1 from...
9.
Tamarina N, Roe M, Philipson L
Islets
. 2014 Dec;
6(1):e27685.
PMID: 25483876
Gene manipulation using Cre-loxP recombination has proven to be an important approach for studying the impact of gene expression on pancreatic β-cell biology. We report the generation of a transgenic...
10.
Kim K, Oh C, Ohara-Imaizumi M, Park S, Namkung J, Yadav V, et al.
Endocrinology
. 2014 Nov;
156(2):444-52.
PMID: 25426873
The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion...