Michael V Levine
Overview
Explore the profile of Michael V Levine including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
465
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Recent Articles
1.
Khelashvili G, Kots E, Cheng X, Levine M, Weinstein H
Commun Biol
. 2022 Sep;
5(1):990.
PMID: 36123525
TMEM16F is a Ca-activated phospholipid scramblase in the TMEM16 family of membrane proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that serves as a translocation pathway for lipids, the...
2.
Tucker M, Piana S, Tan D, Levine M, Shaw D
J Phys Chem B
. 2022 Jun;
126(24):4442-4457.
PMID: 35694853
Although molecular dynamics (MD) simulations have been used extensively to study the structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based systems has been...
3.
Gotfryd K, Boesen T, Mortensen J, Khelashvili G, Quick M, Terry D, et al.
Nat Commun
. 2020 Feb;
11(1):1005.
PMID: 32081981
Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member,...
4.
Doktorova M, Levine M, Khelashvili G, Weinstein H
Biophys J
. 2019 Aug;
117(4):790.
PMID: 31378312
No abstract available.
5.
Levine M, Terry D, Khelashvili G, Siegel Z, Quick M, Javitch J, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(32):15947-15956.
PMID: 31324743
Neurotransmitter:sodium symporters (NSSs) in the SLC6 family terminate neurotransmission by coupling the thermodynamically favorable transport of ions to the thermodynamically unfavorable transport of neurotransmitter back into presynaptic neurons. Results from...
6.
Doktorova M, Levine M, Khelashvili G, Weinstein H
Biophys J
. 2019 Jan;
116(3):487-502.
PMID: 30665693
Because lipid bilayers can bend and stretch in ways similar to thin elastic sheets, physical models of bilayer deformation have utilized mechanical constants such as the moduli for bending rigidity...
7.
Terry D, Kolster R, Quick M, Levine M, Khelashvili G, Zhou Z, et al.
Nat Commun
. 2018 Jan;
9(1):230.
PMID: 29335402
Neurotransmitter:sodium symporters (NSS), targets of antidepressants and psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na)-coupled transport. Substrate and Na are thought to be transported from the extracellular to...
8.
Levine M, Cuendet M, Razavi A, Khelashvili G, Weinstein H
Biophys J
. 2017 Nov;
114(1):10-14.
PMID: 29153319
Allostery plays a crucial role in the mechanism of neurotransmitter-sodium symporters, such as the human dopamine transporter. To investigate the molecular mechanism that couples the transport-associated inward release of the...
9.
Clark L, Dikiy I, Chapman K, Rodstrom K, Aramini J, Levine M, et al.
Elife
. 2017 Oct;
6.
PMID: 28984574
GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain...
10.
Cuendet M, Weinstein H, Levine M
J Chem Theory Comput
. 2016 Oct;
12(12):5758-5767.
PMID: 27766843
Allostery plays a fundamental role in most biological processes. However, little theory is available to describe it outside of two-state models. Here we use a statistical mechanical approach to show...